Eosinophilic Granulomatosis with Polyangiitis Demonstrating IgE-immune Complexes and the Possible Involvement of IgE Autoantibodies

Yasushi Ota; Mutsunori Fujiwara; Yoji Hirabayashi; Toshio Kumasaka; Tamiko Takemura; Rumi Ota; Mitsuya Suzuki; Shigeko Inokuma

doi:10.2169/internalmedicine.54.4588

CASE REPORTS

Eosinophilic Granulomatosis with Polyangiitis Demonstrating IgE-immune Complexes and the Possible Involvement of IgE Autoantibodies

Yasushi Ota, Mutsunori Fujiwara, Yoji Hirabayashi, Toshio Kumasaka, Tamiko Takemura, Rumi Ota, Mitsuya Suzuki, Shigeko Inokuma

Author information

Yasushi Ota
Department of Otorhinolaryngology, Toho University Sakura Medical Center, Japan
Mutsunori Fujiwara
Department of Clinical Laboratory, Japanese Red Cross Medical Center, Japan
Yoji Hirabayashi
Clinical Laboratory Testing Business, Clinical Laboratory Testing Division, Product Planning and Development Division, SRL, Inc., Japan
Toshio Kumasaka
Department of Pathology, Japanese Red Cross Medical Center, Japan
Tamiko Takemura
Department of Pathology, Japanese Red Cross Medical Center, Japan
Rumi Ota
Okamura Otorhinolaryngology Clinic, Japan
Mitsuya Suzuki
Department of Otorhinolaryngology, Toho University Sakura Medical Center, Japan
Shigeko Inokuma
Department of Allergy and Rheumatology, Japanese Red Cross Medical Center, Japan

Keywords: MPO-ANCA, eosinophil, Churg-Strauss syndrome

JOURNAL OPEN ACCESS

2015 Volume 54 Issue 20 Pages 2687-2691

DOI https://doi.org/10.2169/internalmedicine.54.4588

Details

Abstract

We herein report a case of female eosinophilic granulomatosis with polyangiitis (EGPA) in which polyethylene glycol (PEG) precipitation was used to evaluate the patient's levels IgE-immune complexes (IC). Her serum IgE (7,110 IU/mL) and IgE-IC (1,880 IU/mL) levels were observed with an IgE PEG precipitated index of 26.4%. We speculate that the circulating IgE-IC were formed by anti-neutrophil IgE autoantibodies. Therefore, the large amount of IgE autoantibodies in the patient's serum appears to have induced a constant allergic pathology. This pathology may have resulted in a marked infiltration of eosinophils into the tissues, as well as intensified the EGPA pathology.

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