Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Evaluation of Myocardial Triglyceride Accumulation Assessed on 1H-Magnetic Resonance Spectroscopy in Apparently Healthy Japanese Subjects
Eiryu SaiKazunori ShimadaTakayuki YokoyamaShuji SatoYuji NishizakiTetsuro MiyazakiMakoto HikiYoshifumi TamuraShigeki AokiHirotaka WatadaRyuzo KawamoriHiroyuki Daida
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2015 Volume 54 Issue 4 Pages 367-373


Objective Proton magnetic resonance spectroscopy (1H-MRS) enables the clinician to noninvasively assess the amount of ectopic fat in the liver, skeletal muscle and myocardium. Recent studies have reported that the myocardial triglyceride (TG) content is associated with aging, metabolic disorders and cardiac dysfunction. However, the clinical usefulness of myocardial TG measurements in Japanese subjects has not been fully investigated.
Methods The myocardial TG content was evaluated using 1H-MRS in 37 apparently healthy Japanese subjects, and the left ventricular function was measured on cardiac magnetic resonance imaging (MRI). Blood pressure, body composition and biochemical markers were measured in a fasting state, and cardiopulmonary exercise testing (CPX) was performed to evaluate exercise capacity.
Results The mean myocardial TG content was 0.85±0.40%. The myocardial TG content was significantly associated with the percent body fat (r=0.39), serum triglyceride level (r=0.40), estimated glomerular filtration rate (r=-0.37), anaerobic threshold (r=-0.36), maximal load of CPX (r=0.39), left ventricular end-diastolic volume (r=-0.41) and left ventricular end-systolic volume (LVESV) (r=-0.51) (all: p<0.05). In a multivariate analysis, the LVESV was found to be an independent factor of the myocardial TG content.
Conclusion 1H-MRS may be useful for assessing the associations between the myocardial TG content and various clinical parameters, including those reflecting obesity, metabolic disorders, cardiac morphology and exercise capacity, noninvasively, even in Japanese subjects.

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© 2015 by The Japanese Society of Internal Medicine
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