Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Methotrexate-related Primary Hepatic Lymphoma in a Patient with Rheumatoid Arthritis
Koichiro MiyagawaMichihiko ShibataHirotsugu NoguchiTsuguru HayashiShinji OeMasaaki HiuraShintaro AbeMasaru Harada
Author information
JOURNAL OPEN ACCESS

2015 Volume 54 Issue 4 Pages 401-405

Details
Abstract

A 56-year-old woman with rheumatoid arthritis treated with methotrexate (MTX) was admitted to our hospital due to multiple liver tumors. Contrast-enhanced computed tomography (CT) revealed multiple hypovascular masses, and 18F-fluorodeoxyglucose positron emission tomography CT showed diffuse abnormal accumulation in the liver only. We therefore made a diagnosis of MTX-related primary hepatic lymphoma (MTX-PHL) exhibiting features of diffuse large B-cell lymphoma. Although MTX has been reported to increase the risk of lymphoproliferative disorders, MTX-PHL has not been reported previously. The present case is the first case in which MTX appears to have been involved in the development of PHL.

Information related to the author
© 2015 by The Japanese Society of Internal Medicine
Previous article Next article
feedback
Top