Recurrence after Radiotherapy for Gastric Mucosa-associated Lymphoid Tissue (MALT) Lymphoma with Trisomy 18

Hisashi Ishikawa; Masaya Iwamuro; Hiroyuki Okada; Keisuke Hori; Masahide Kita; Seiji Kawano; Yoshiro Kawahara; Takehiro Tanaka; Eisei Kondo; Tadashi Yoshino; Kazuhide Yamamoto

doi:10.2169/internalmedicine.54.3784

CASE REPORTS

Recurrence after Radiotherapy for Gastric Mucosa-associated Lymphoid Tissue (MALT) Lymphoma with Trisomy 18

Hisashi Ishikawa, Masaya Iwamuro, Hiroyuki Okada, Keisuke Hori, Masahide Kita, Seiji Kawano, Yoshiro Kawahara, Takehiro Tanaka, Eisei Kondo, Tadashi Yoshino, Kazuhide Yamamoto

Author information

Hisashi Ishikawa
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan
Masaya Iwamuro
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan
Department of Molecular Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan
Hiroyuki Okada
Department of Endoscopy, Okayama University Hospital, Japan
Keisuke Hori
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan
Masahide Kita
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan
Seiji Kawano
Department of Endoscopy, Okayama University Hospital, Japan
Yoshiro Kawahara
Department of Endoscopy, Okayama University Hospital, Japan
Takehiro Tanaka
Department of Pathology, Okayama University Hospital, Japan
Eisei Kondo
Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan
Tadashi Yoshino
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan
Kazuhide Yamamoto
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan

Keywords: extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue, MALT lymphoma, gastric lymphoma, trisomy 18

JOURNAL OPEN ACCESS

2015 Volume 54 Issue 8 Pages 911-916

DOI https://doi.org/10.2169/internalmedicine.54.3784

Details

Abstract

A 36-year-old Japanese woman presented with extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in the stomach. The gastric lesions only partially improved after eradication therapy for Helicobacter pylori. A fluorescence in situ hybridization analysis revealed no fusion genes of API2-MALT1, although trisomy of chromosome 18 was identified. Radiation therapy was initiated to treat the gastric lymphoma lesions, resulting in complete remission. However, MALT lymphoma recurred in the stomach 16 months later. This case indicates that intensive follow-up is required for MALT lymphoma associated with chromosomal aberrations in order to detect early relapse.

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