Burkitt Lymphoma Preceded by Autoimmune Hemolytic Anemia due to Anti-D Antibody

Yoshimi Mizuno; Yuji Shimura; Shigeo Horiike; Tomoko Takimoto; Saori Maegawa; Kazuna Tanba; Yayoi Matsumura-Kimoto; Yukari Sumida; Shotaro Tatekawa; Taku Tsukamoto; Yoshiaki Chinen; Shinsuke Mizutani; Hisao Nagoshi; Mio Yamamoto-Sugitani; Yosuke Matsumoto; Tsutomu Kobayashi; Junya Kuroda; Masafumi Taniwaki

doi:10.2169/internalmedicine.55.6564

CASE REPORTS

Burkitt Lymphoma Preceded by Autoimmune Hemolytic Anemia due to Anti-D Antibody

Yoshimi Mizuno, Yuji Shimura, Shigeo Horiike, Tomoko Takimoto, Saori Maegawa, Kazuna Tanba, Yayoi Matsumura-Kimoto, Yukari Sumida, Shotaro Tatekawa, Taku Tsukamoto, Yoshiaki Chinen, Shinsuke Mizutani, Hisao Nagoshi, Mio Yamamoto-Sugitani, Yosuke Matsumoto, Tsutomu Kobayashi, Junya Kuroda, Masafumi Taniwaki

Author information

Yoshimi Mizuno
Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan
Yuji Shimura
Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan
Shigeo Horiike
Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan
Department of Transfusion and Cell Medicine, Kyoto Prefectural University of Medicine, Japan
Tomoko Takimoto
Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan
Saori Maegawa
Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan
Kazuna Tanba
Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan
Yayoi Matsumura-Kimoto
Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan
Yukari Sumida
Department of Transfusion and Cell Medicine, Kyoto Prefectural University of Medicine, Japan
Shotaro Tatekawa
Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan
Taku Tsukamoto
Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan
Yoshiaki Chinen
Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan
Shinsuke Mizutani
Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan
Hisao Nagoshi
Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan
Mio Yamamoto-Sugitani
Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan
Yosuke Matsumoto
Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan
Tsutomu Kobayashi
Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan
Junya Kuroda
Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan
Masafumi Taniwaki
Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan

Keywords: Burkitt lymphoma, autoimmune hemolytic anemia, anti-D antibody

JOURNAL OPEN ACCESS

2016 Volume 55 Issue 16 Pages 2253-2258

DOI https://doi.org/10.2169/internalmedicine.55.6564

Details

Abstract

We herein report a rare case of Burkitt lymphoma (BL) preceded by autoimmune hemolytic anemia (AIHA) caused by autoantibodies against D antigen. After a partial response to AIHA with prednisolone (PSL) treatment for 7 months, the patient developed BL with a t(8;22)(q24;q11.2) chromosomal translocation. Intensive immunochemotherapy, including rituximab, led to a complete response (CR) of BL; however, anti-D antibody remained detectable in the plasma and antibody-dissociated solution from erythrocytes, thus continuous therapy with PSL was necessary even after achievement of the CR. BL with AIHA is extremely rare, with only one previously reported case in the literature.

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