Regression of Cecal MALT Lymphoma after Antibiotic Treatment in a Patient with Helicobacter pylori Infection

Ryo Yuge; Yasuhiko Kitadai; Shinji Tanaka; Naohiro Uraoka; Kazuhiro Sentani; Wataru Yasui; Kazuaki Chayama

doi:10.2169/internalmedicine.55.5937

CASE REPORTS

Regression of Cecal MALT Lymphoma after Antibiotic Treatment in a Patient with Helicobacter pylori Infection

Ryo Yuge, Yasuhiko Kitadai, Shinji Tanaka, Naohiro Uraoka, Kazuhiro Sentani, Wataru Yasui, Kazuaki Chayama

Author information

Ryo Yuge
Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
Yasuhiko Kitadai
Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
Shinji Tanaka
Department of Endoscopy, Hiroshima University Hospital, Japan
Naohiro Uraoka
Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
Kazuhiro Sentani
Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
Wataru Yasui
Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
Kazuaki Chayama
Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan

Keywords: MALT, Helicobacter pylori

JOURNAL OPEN ACCESS

2016 Volume 55 Issue 2 Pages 135-139

DOI https://doi.org/10.2169/internalmedicine.55.5937

Details

Abstract

A 63-year-old man with abdominal discomfort was referred to our hospital. Colonoscopy revealed a hemispherical-shaped protruding cecal mass of approximately 10 mm in size with a normal mucosal surface. Biopsy specimens showed nodules consisting of the proliferation of atypical lymphoid cells. Mucosa-associated lymphoid tissue (MALT) lymphoma was diagnosed based on the histological and immunohistochemical findings. Since upper gastrointestinal endoscopy demonstrated Helicobacter pylori-associated atrophic gastritis, eradication therapy was administered. The cecal mass disappeared completely within three months after triple therapy. Therefore, H. pylori eradication therapy may be a useful treatment option for cecal MALT lymphoma.

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