Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Successful Treatment of TAFRO Syndrome with Tocilizumab, Prednisone, and Cyclophosphamide
Taku KikuchiTakayuki ShimizuTakaaki ToyamaRyohei AbeShinichiro Okamoto
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JOURNALS OPEN ACCESS

2017 Volume 56 Issue 16 Pages 2205-2211

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Abstract

TAFRO syndrome is a rare systemic inflammatory disease characterized by thrombocytopenia, pleural effusion, fever, renal dysfunction, reticulin fibrosis of the bone marrow, and organomegaly. The clinical course varies significantly among patients. However, the prognosis is usually dismal in patients with severe TAFRO syndrome, and no optimal treatment has yet been established. We herein describe the first case of TAFRO syndrome, which was successfully treated with combination therapy consisting of tocilizumab, prednisone, and cyclophosphamide.

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© 2017 by The Japanese Society of Internal Medicine
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