Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Renal Cell Carcinoma and a Pancreatic Neuroendocrine Tumor: A Coincidence or Instance of Von Hippel-Lindau Disease?
Hiroyuki MatsubayashiMasashi NiwakawaKatsuhiko UesakaKeiko SasakiYoshimi KiyozumiHirotoshi IshiwatariKinichi HottaKenichiro ImaiSayo ItoKohei TakizawaMasaki TanakaNoboru KawataNaomi KakushimaHiroyuki Ono
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JOURNALS OPEN ACCESS

2017 Volume 56 Issue 17 Pages 2281-2284

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Abstract

We herein report a rare case of a 79-year-old man who presented with the simultaneous occurrence of pancreatic neuroendocrine tumors (PNET) and renal cell carcinomas (RCC), without any other Von Hippel-Lindau (VHL)-associated lesions or any pertinent family history. Computed tomography showed vascular-rich solid lesions in the left kidney and the pancreatic tail, measuring 72 mm and 15 mm in size, respectively. Preoperatively, RCC with pancreatic metastasis was suspected and laparotomy was performed. However, the resected specimens revealed a different tumor histology, namely renal clear cell carcinoma (G2, pT3) and PNET (G1, pT3). The patient and his family refused genetic testing, however, so far, the patient has not developed any VHL-associated lesions for more than four years.

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© 2017 by The Japanese Society of Internal Medicine
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