Fulminant Tracheobronchial Aspergillosis in an Apparently Healthy Adult

Hayato Moribuchi; Rumi Sato; Shuntaro Matsushima; Masaki Tominaga; Jun Sasaki; Masayuki Nakamura; Yuki Sakazaki; Mamoru Nishiyama; Tomoaki Hoshino; Tomotaka Kawayama

doi:10.2169/internalmedicine.3857-19

CASE REPORTS

Fulminant Tracheobronchial Aspergillosis in an Apparently Healthy Adult

Hayato Moribuchi, Rumi Sato, Shuntaro Matsushima, Masaki Tominaga, Jun Sasaki, Masayuki Nakamura, Yuki Sakazaki, Mamoru Nishiyama, Tomoaki Hoshino, Tomotaka Kawayama

Author information

Hayato Moribuchi
Division of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine, Japan
Rumi Sato
Division of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine, Japan
Respiratory Medicine, Asakura Medical Association Hospital, Japan
Shuntaro Matsushima
Kurume Medical Resident Center, Kurume University Hospital, Japan
Masaki Tominaga
Division of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine, Japan
Jun Sasaki
Division of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine, Japan
Masayuki Nakamura
Division of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine, Japan
Yuki Sakazaki
Division of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine, Japan
Mamoru Nishiyama
Division of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine, Japan
Tomoaki Hoshino
Division of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine, Japan
Tomotaka Kawayama
Division of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine, Japan

Keywords: fulminant, tracheobronchial aspergillosis, healthy individual

JOURNAL OPEN ACCESS

2020 Volume 59 Issue 10 Pages 1295-1298

DOI https://doi.org/10.2169/internalmedicine.3857-19

Details

Abstract

A 56-year-old healthy man who was a current smoker died from fulminant tracheobronchial aspergillosis despite a month of treatment with a combination of intravenous anti-fungal agents that had been started immediately after the diagnosis. This case report is important for understanding and managing fulminant Aspergillus infections in healthy subjects, although the pathogenesis and underlying pathways are still unknown.

Corresponding author

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