Hyperemesis-induced Wernicke-Korsakoff Syndrome due to Hypergastrinemia during Long-term Treatment with Proton Pump Inhibitors

Rei Miyanaga; Shin Hisahara; Ikkei Ohhashi; Daisuke Yamamoto; Akihiro Matsumura; Syuuichirou Suzuki; Katsumasa Tanimoto; Masahiro Hirakawa; Jun Kawamata; Junji Kato; Shun Shimohama

doi:10.2169/internalmedicine.5168-20

CASE REPORTS

Hyperemesis-induced Wernicke-Korsakoff Syndrome due to Hypergastrinemia during Long-term Treatment with Proton Pump Inhibitors

Rei Miyanaga, Shin Hisahara, Ikkei Ohhashi, Daisuke Yamamoto, Akihiro Matsumura, Syuuichirou Suzuki, Katsumasa Tanimoto, Masahiro Hirakawa, Jun Kawamata, Junji Kato, Shun Shimohama

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Keywords: Wernicke-Korsakoff syndrome (WKS), hypergastrinemia, proton pump inhibitor (PPI), hyperemesis, vitamin B1

JOURNAL OPEN ACCESS

2020 Volume 59 Issue 21 Pages 2783-2787

DOI https://doi.org/10.2169/internalmedicine.5168-20

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Abstract

We herein report a patient with Wernicke-Korsakoff syndrome (WKS) who had neither a history of alcoholism or of history of gastric surgery. A 56-year-old woman was transferred to our hospital because of the loss of consciousness and she was diagnosed to have Wernicke encephalopathy. She showed proton pump inhibitor-induced refractory hypergastrinemia with the subsequent development of hyperemesis and a vitamin B1 deficiency.

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