Early Detection of High-grade Biliary Intraepithelial Neoplasia (BilIN-3) in the Cystic Duct Visualized by SpyGlass DS Cholangioscopy

Katsuyuki Miyabe; Kenji Notohara; Go Asano; Akihisa Kato; Naruomi Jinno; Makoto Natsume; Yasuki Hori; Michihiro Yoshida; Itaru Naitoh; Ken Tsuboi; Yoichi Matsuo; Hirotaka Ohara; Kazuki Hayashi; Hiromi Kataoka

doi:10.2169/internalmedicine.5072-20

CASE REPORTS

Early Detection of High-grade Biliary Intraepithelial Neoplasia (BilIN-3) in the Cystic Duct Visualized by SpyGlass DS Cholangioscopy

Katsuyuki Miyabe, Kenji Notohara, Go Asano, Akihisa Kato, Naruomi Jinno, Makoto Natsume, Yasuki Hori, Michihiro Yoshida, Itaru Naitoh, Ken Tsuboi, Yoichi Matsuo, Hirotaka Ohara, Kazuki Hayashi, Hiromi Kataoka

Author information

Katsuyuki Miyabe
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Department of Gastroenterology, Japanese Red Cross Nagoya Daini Hospital, Japan
Kenji Notohara
Department of Anatomic Pathology, Kurashiki Central Hospital, Japan
Go Asano
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Akihisa Kato
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Naruomi Jinno
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Makoto Natsume
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Yasuki Hori
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Michihiro Yoshida
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Itaru Naitoh
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Ken Tsuboi
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Japan
Yoichi Matsuo
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Japan
Hirotaka Ohara
Department of Community-based Medical Education, Nagoya City University Graduate School of Medical Sciences, Japan
Kazuki Hayashi
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Hiromi Kataoka
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan

Keywords: cystic duct tumor, cystic duct, cholangioscopy, BilIN-3, high-grade biliary intraepithelial neoplasia

JOURNAL OPEN ACCESS

2021 Volume 60 Issue 1 Pages 47-52

DOI https://doi.org/10.2169/internalmedicine.5072-20

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Abstract

An 84-year-old man was admitted with epigastralgia. Computed tomography showed contrast-enhanced wall thickness in the cystic duct. An endoscopic examination revealed short irregular stricture in the cystic duct, and per-oral cholangioscopy revealed a reddish papillary tumor at the stricture site. Surgical resection revealed high-grade biliary intraepithelial neoplasia (BilIN) at the stricture site of the cystic duct. To our knowledge, this is the first case of a solitary high-grade BilIN epithelium in the cystic duct detected by per-oral cholangioscopy.

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