Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Persistent Expression of Recipient-type ABH Antigen after ABO-incompatible Allogeneic Hematopoietic Stem Cell Transplantation
Yukiko Misaki, Shinichi Kako, Shunto Kawamura, Junko Takeshita, Nozomu Yoshino, Kazuki Yoshimura, Ayumi Gomyo, Yu Akahoshi, Masaharu Tamaki, Machiko Kusuda, Kazuaki Kameda, Hidenori Wada, Koji Kawamura, Miki Sato, Kiriko Terasako-Saito, Shun-ichi Kimura, Hideki Nakasone, Koji Kishino, Kazuo Muroi, Yoshinobu Kanda
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Keywords: allogeneic HSCT, blood type, ABO blood group antigen, ABO-incompatibility, transfusion
JOURNAL OPEN ACCESS

2022 Volume 61 Issue 12 Pages 1887-1890

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Abstract

In general, the recipient's ABO blood type changes to the donor's ABO blood type after ABO-incompatible allogeneic hematopoietic stem cell transplantation (HSCT). However, we experienced a 26-year-old male with acute myelogenous leukemia (AML) who underwent ABO-incompatible HSCT twice and persistently showed his original blood type even after demonstrating complete donor-type chimerism. Based on the results of various examinations, we considered that the antigen of the recipient's original blood type persistently synthesized in the recipient's non-hematopoietic organs was secreted and adsorbed on the surface of donor-derived RBCs. We should therefore perform detailed examinations to determine the precise blood type after ABO-incompatible HSCT.

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© 2022 by The Japanese Society of Internal Medicine
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