Usual Interstitial Pneumonia Pattern Interstitial Lung Disease Developed in a Patient with IgG4-related Chronic Sclerosing Sialadenitis

Hiroshi Yamamoto; Masamichi Komatsu; Kei Sonehara; Yuichi Ikuyama; Kazuhisa Urushihata; Kazunari Tateishi; Yoshiaki Kitaguchi; Atsuhito Ushuiki; Shiho Asaka; Takeshi Uehara; Satoshi Kawakami; Kentaro Mori; Kazutoshi Hamanaka; Kenichi Nishie; Akira Hebisawa; Masayuki Hanaoka

doi:10.2169/internalmedicine.8937-21

CASE REPORTS

Usual Interstitial Pneumonia Pattern Interstitial Lung Disease Developed in a Patient with IgG4-related Chronic Sclerosing Sialadenitis

Hiroshi Yamamoto, Masamichi Komatsu, Kei Sonehara, Yuichi Ikuyama, Kazuhisa Urushihata, Kazunari Tateishi, Yoshiaki Kitaguchi, Atsuhito Ushuiki, Shiho Asaka, Takeshi Uehara, Satoshi Kawakami, Kentaro Mori, Kazutoshi Hamanaka, Kenichi Nishie, Akira Hebisawa, Masayuki Hanaoka

Author information

Hiroshi Yamamoto
First Department of Internal Medicine, Shinshu University School of Medicine, Japan
Masamichi Komatsu
First Department of Internal Medicine, Shinshu University School of Medicine, Japan
Kei Sonehara
First Department of Internal Medicine, Shinshu University School of Medicine, Japan
Yuichi Ikuyama
First Department of Internal Medicine, Shinshu University School of Medicine, Japan
Kazuhisa Urushihata
First Department of Internal Medicine, Shinshu University School of Medicine, Japan
Kazunari Tateishi
First Department of Internal Medicine, Shinshu University School of Medicine, Japan
Yoshiaki Kitaguchi
First Department of Internal Medicine, Shinshu University School of Medicine, Japan
Atsuhito Ushuiki
First Department of Internal Medicine, Shinshu University School of Medicine, Japan
Shiho Asaka
Department of Laboratory Medicine, Shinshu University School of Medicine, Japan
Takeshi Uehara
Department of Laboratory Medicine, Shinshu University School of Medicine, Japan
Satoshi Kawakami
Department of Radiology, Shinshu University School of Medicine, Japan
Kentaro Mori
Department of Otorhinolaryngology, Shinshu University School of Medicine, Japan
Kazutoshi Hamanaka
Department of Surgery, Division of General Thoracic Surgery, Shinshu University School of Medicine, Japan
Kenichi Nishie
Department of Respiratory Medicine, Iida Municipal Hospital, Japan
Akira Hebisawa
Division of Clinical Pathology, Asahi General Hospital, Japan
Masayuki Hanaoka
First Department of Internal Medicine, Shinshu University School of Medicine, Japan

Keywords: immunoglobulin (Ig) G4, immunoglobulin (Ig) G4-related disease (IgG4-RD), progressive fibrosing, interstitial pneumonia, usual interstitial pneumonia (UIP)

JOURNAL OPEN ACCESS

2022 Volume 61 Issue 17 Pages 2637-2642

DOI https://doi.org/10.2169/internalmedicine.8937-21

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Abstract

A 69-year-old man was diagnosed with immunoglobulin (Ig) G4-related disease (IgG4-RD) at 62 years old. At that time, he had high serum IgG4 levels and bilateral submandibular gland swelling on CT; thus, a gland biopsy was performed. Because a reticular shadow was found on chest CT, a lung surgical biopsy was also performed. The specimens revealed usual interstitial pneumonia (UIP) pattern interstitial pneumonia with some IgG4-positive cells. The patient was subsequently followed up without treatment. His forced vital capacity and radiological findings progressively deteriorated, consistent with UIP pattern interstitial lung disease but different from a lung lesion of IgG4-RD.

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