Anti-SOX1 Antibody-positive Small-cell Lung Cancer That Triggered Opsoclonus

Yuki Chiko; Yuka Sugisaki; Keiji Miyoshi; Daisuke Morichika; Yuka Beika; Akihiko Taniguchi; Eiki Ichihara; Toshiaki Okada

doi:10.2169/internalmedicine.0168-22

CASE REPORTS

Anti-SOX1 Antibody-positive Small-cell Lung Cancer That Triggered Opsoclonus

Yuki Chiko, Yuka Sugisaki, Keiji Miyoshi, Daisuke Morichika, Yuka Beika, Akihiko Taniguchi, Eiki Ichihara, Toshiaki Okada

Author information

Yuki Chiko
Department of Internal Medicine, Independent Administrative Agency, National Hospital Organization, Fukuyama Medical Center, Japan
Yuka Sugisaki
Department of Internal Medicine, Independent Administrative Agency, National Hospital Organization, Fukuyama Medical Center, Japan
Keiji Miyoshi
Department of Respiratory Medicine, Independent Administrative Agency, National Hospital Organization, Fukuyama Medical Center, Japan
Daisuke Morichika
Department of Respiratory Medicine, Independent Administrative Agency, National Hospital Organization, Fukuyama Medical Center, Japan
Yuka Beika
Department of Respiratory Medicine, Independent Administrative Agency, National Hospital Organization, Fukuyama Medical Center, Japan
Akihiko Taniguchi
Department of Respiratory Medicine, Independent Administrative Agency, National Hospital Organization, Fukuyama Medical Center, Japan
Eiki Ichihara
Department of Allergy and Respiratory Medicine, Okayama University Hospital, Japan
Toshiaki Okada
Department of Respiratory Medicine, Independent Administrative Agency, National Hospital Organization, Fukuyama Medical Center, Japan

Keywords: opsoclonus, small-cell lung cancer, paraneoplastic neurological syndrome, anti-SOX1 antibody

JOURNAL OPEN ACCESS

2023 Volume 62 Issue 6 Pages 881-884

DOI https://doi.org/10.2169/internalmedicine.0168-22

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Details

Abstract

A 72-year-old woman with opsoclonus visited our hospital and was diagnosed with small-cell lung cancer. Blood tests revealed anti-SOX1 antibodies, so the patient was diagnosed with paraneoplastic opsoclonus-myoclonus syndrome. After steroid pulse therapy was started, chemotherapy of treatment, the opsoclonus showed an improving trend. Anti-Ri and anti-Hu antibodies have been reported as autoantibodies associated with neoplastic opsoclonus-myoclonus syndrome; however, there are no such reports concerning anti-SOX1 antibody. Therefore, this is a valuable case.

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