Interstitial Pneumonia Associated with Nodal T-follicular Helper Cell Lymphoma

Satoshi Nakamura; Tomotsugu Takano; Kousei Nakatsuru; Kazuya Tsubouchi; Takuji Yamauchi; Mikiko Hashisako; Takeshi Iwasaki; Isamu Okamoto

doi:10.2169/internalmedicine.3601-24

CASE REPORTS

Interstitial Pneumonia Associated with Nodal T-follicular Helper Cell Lymphoma

Satoshi Nakamura, Tomotsugu Takano, Kousei Nakatsuru, Kazuya Tsubouchi, Takuji Yamauchi, Mikiko Hashisako, Takeshi Iwasaki, Isamu Okamoto

Author information

Satoshi Nakamura
Department of Respiratory Medicine, Kyushu University Hospital, Japan
Tomotsugu Takano
Department of Respiratory Medicine, Kyushu University Hospital, Japan
Kousei Nakatsuru
Department of Respiratory Medicine, Kyushu University Hospital, Japan
Kazuya Tsubouchi
Department of Respiratory Medicine, Kyushu University Hospital, Japan
Takuji Yamauchi
Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Japan
Mikiko Hashisako
Division of Diagnostic Pathology, Kyushu University Hospital, Japan
Takeshi Iwasaki
Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Japan
Isamu Okamoto
Department of Respiratory Medicine, Kyushu University Hospital, Japan

Keywords: case report, eosinophilia, interstitial pneumonia, interstitial pneumonia with autoimmune features, nodal T-follicular helper cell lymphoma

JOURNAL OPEN ACCESS

2024 Volume 63 Issue 23 Pages 3227-3231

DOI https://doi.org/10.2169/internalmedicine.3601-24

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Abstract

Nodal T-follicular helper cell lymphoma (nTFHL), a hematologic neoplasm originating from T-follicular helper (TFH) cells, occasionally presents with pulmonary radiographic abnormalities, without neoplastic cellular infiltration. However, the precise mechanisms underlying non-neoplastic pulmonary opacities in patients with nTFHL remain unclear. Previous reports have shown that TFH cell abnormalities are associated with collagen disease and interstitial pneumonia with autoimmune features (IPAF). We herein report a patient with nTFHL accompanied by interstitial pneumonia diagnosed via lung and lymph node biopsies. These findings suggest the need to rule out nTFHL before diagnosing IPAF.

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