Central Nervous System Lymphoma Harboring the JAK2 V617F Mutation that Developed after a 20-year History of Polycythemia Vera

Natsuki Kajikawa; Yoshimoto Seki; Takayuki Fujio; Yasushi Okoshi; Mitsuo Hori; Hitoaki Saito; Tatsuo Iijima; Hiroshi Kojima

doi:10.2169/internalmedicine.1093-18

This article has now been updated. Please use the final version.

Central Nervous System Lymphoma Harboring the JAK2 V617F Mutation that Developed after a 20-year History of Polycythemia Vera

Natsuki Kajikawa, Yoshimoto Seki, Takayuki Fujio, Yasushi Okoshi, Mitsuo Hori, Hitoaki Saito, Tatsuo Iijima, Hiroshi Kojima

Author information

Keywords: polycythemia vera, primary central nervous system lymphoma, B-cell lymphoma, JAK2 V617F mutation

JOURNAL OPEN ACCESS Advance online publication

Article ID: 1093-18

DOI https://doi.org/10.2169/internalmedicine.1093-18

The final version of this article is now available: Vol. 57 (2018), No. 22 pp. 3293-3297

Details

Abstract

A 78-year-old man who had a 20-year history of polycythemia vera (PV) with a JAK2 V617F mutation presented with gradually progressive disturbance of consciousness. Hyper-intense lesions in the peri-lateral ventricular area and left cerebellar hemisphere were observed by T2-weighted and fluid-attenuated inversion recovery magnetic resonance imaging. Cytologic and genetic analyses of the lymphoma cells obtained from his cerebrospinal fluid established the diagnosis of B-cell lymphoma. No lesions outside of the brain were recognized. Because of his poor general condition, he was not treated actively. A postmortem analysis revealed a JAK2 V617F mutation in the lymphoma cells, suggesting their origin was a PV clone.

Corresponding author

Register with J-STAGE for free!