Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918

This article has now been updated. Please use the final version.

Severe TAFRO Syndrome Mimicking Hepatorenal Syndrome Successfully Treated with a Multidisciplinary Approach: A Case Report and Literature Review
Shinya YamamotoKen WellsKeisuke MoritaKatsuya TanigakiKoji MuroMinami MatsumotoHirotsugu NakaiYasuyuki AraiShuji AkizukiKen TakahashiSachiko MinamiguchiShingo FukumaMotoko Yanagita
Author information
JOURNAL OPEN ACCESS Advance online publication

Article ID: 1178-22

Details
Abstract

Finding the ideal balance between efficacy and safety of immunosuppression is challenging, particularly in cases of severe TAFRO syndrome. We herein report a 60-year-old man diagnosed with grade 5 TAFRO syndrome mimicking hepatorenal syndrome that was successfully treated by glucocorticoid, tocilizumab, and cyclosporin despite virus infection. Furthermore, by examining 14 peer-reviewed remission cases, we revealed that the recovery periods among inflammation, renal dysfunction, and thrombocytopenia were quite different, with recovery from thrombocytopenia notably slow. All patients requiring dialysis were successfully withdrawn from dialysis, and the reversibility from kidney injury was good. This clinical information will help clinicians plan treatments and tailor the intensity of immunosuppression.

Content from these authors
© 2023 by The Japanese Society of Internal Medicine
feedback
Top