Multiple Placental Infarcts in a Pregnant Woman with Essential Thrombocythemia: A Case Report

Yoko Edahiro; Jun Ando; Toshifumi Suzuki; Yuki Fukumura; Azuchi Masuda; Shiori Sakayori; Jun Takeda; Yojiro Maruyama; Shintaro Makino; Atsuo Itakura; Norio Komatsu

doi:10.2169/internalmedicine.1311-18

This article has now been updated. Please use the final version.

Multiple Placental Infarcts in a Pregnant Woman with Essential Thrombocythemia: A Case Report

Yoko Edahiro, Jun Ando, Toshifumi Suzuki, Yuki Fukumura, Azuchi Masuda, Shiori Sakayori, Jun Takeda, Yojiro Maruyama, Shintaro Makino, Atsuo Itakura, Norio Komatsu

Author information

Yoko Edahiro
Department of Hematology, Juntendo University School of Medicine, Japan
Jun Ando
Department of Hematology, Juntendo University School of Medicine, Japan
Toshifumi Suzuki
Department of Obstetrics and Gynecology, Juntendo University School of Medicine, Japan
Yuki Fukumura
Department of Human Pathology, Juntendo University School of Medicine, Japan
Azuchi Masuda
Department of Hematology, Juntendo University School of Medicine, Japan
Shiori Sakayori
Department of Obstetrics and Gynecology, Juntendo University School of Medicine, Japan
Jun Takeda
Department of Obstetrics and Gynecology, Juntendo University School of Medicine, Japan
Yojiro Maruyama
Department of Obstetrics and Gynecology, Juntendo University School of Medicine, Japan
Shintaro Makino
Department of Obstetrics and Gynecology, Juntendo University School of Medicine, Japan
Atsuo Itakura
Department of Obstetrics and Gynecology, Juntendo University School of Medicine, Japan
Norio Komatsu
Department of Hematology, Juntendo University School of Medicine, Japan

Keywords: myeloproliferative neoplasms, essential thrombocythemia, pregnancy, placental infarcts, aspirin, low-molecular-weight heparin

JOURNAL OPEN ACCESS Advance online publication

Article ID: 1311-18

DOI https://doi.org/10.2169/internalmedicine.1311-18

The final version of this article is now available: Vol. 57 (2018), No. 24 pp. 3647-3650

Details

Abstract

Myeloproliferative neoplasms (MPNs), including polycythemia vera, essential thrombocythemia (ET), and primary myelofibrosis, mainly occur in older patients, but have also been reported in younger patients. A "second peak" occurs in female patients in their thirties, particularly in ET; thus, the management of pregnancy is often discussed.

We herein present the case of a 33-year-old woman with a high platelet count and multiple placental infarcts during delivery who was subsequently diagnosed with ET. Although there are no worldwide guidelines for the management of MPNs in pregnancy, the risk of thrombosis is markedly increased in these patients, and antithrombotic therapy should be considered.

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