Anti-melanoma Differentiation-associated Gene 5 Antibody-positive Dermatomyositis Presenting as Refractory Gingivitis at the First Clinical Manifestation: A Case Report

Eiko Kawakami; Tomohisa Uchida; Naoki Iwamoto; Kazusato Hara; Kazuhiro Egashira; Atsushi Kawakami

doi:10.2169/internalmedicine.1621-23

This article has now been updated. Please use the final version.

Anti-melanoma Differentiation-associated Gene 5 Antibody-positive Dermatomyositis Presenting as Refractory Gingivitis at the First Clinical Manifestation: A Case Report

Eiko Kawakami, Tomohisa Uchida, Naoki Iwamoto, Kazusato Hara, Kazuhiro Egashira, Atsushi Kawakami

Author information

Eiko Kawakami
Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan
Tomohisa Uchida
Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan
Naoki Iwamoto
Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan
Kazusato Hara
Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan
Rheumatic and Collagen Disease Center, Sasebo Chuo Hospital, Japan
Kazuhiro Egashira
Department of Regenerative Oral Surgery, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
Atsushi Kawakami
Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan

Keywords: dermatomyositis, anti-melanoma differentiation-associated gene 5 (MDA5) antibody, gingivitis

JOURNAL OPEN ACCESS Advance online publication

Article ID: 1621-23

DOI https://doi.org/10.2169/internalmedicine.1621-23

The final version of this article is now available: Vol. 63 (2024), No. 1 pp. 131-134

Details

Abstract

We herein report a case of melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis that developed in a patient with refractory gingivitis. The diagnosis of anti-MDA5 antibody-positive dermatomyositis was made based on a characteristic skin rash, weakness of proximal muscles, interstitial pneumonia, and positivity for anti-MDA5 antibody. The patient was started on triple therapy with high-dose prednisolone, tacrolimus, and intravenous cyclophosphamide. After treatment, the refractory gingivitis disappeared, and the other skin rash and interstitial lung disease also improved. In the diagnosis and treatment of anti-MDA5 antibody-positive dermatomyositis, it is necessary to pay attention to the intraoral findings, including the gingiva.

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