Two Cases with Acute Promyelocytic Leukemia and HIV: Case Reports and a Review of the Literature

Akane Kunitomi; Yuta Hasegawa; Junji lmamura; Yoshiyuki Yokomaku; Takashi Tokunaga; Yasuhiko Miyata; Hiroatsu Iida; Hirokazu Nagai

doi:10.2169/internalmedicine.1662-18

This article has now been updated. Please use the final version.

Two Cases with Acute Promyelocytic Leukemia and HIV: Case Reports and a Review of the Literature

Akane Kunitomi, Yuta Hasegawa, Junji lmamura, Yoshiyuki Yokomaku, Takashi Tokunaga, Yasuhiko Miyata, Hiroatsu Iida, Hirokazu Nagai

Author information

Akane Kunitomi
Department of Hematology, National Hospital Organization Nagoya Medical Center, Japan
Yuta Hasegawa
Department of Hematology, National Hospital Organization Nagoya Medical Center, Japan
Junji lmamura
Infectious Diseases and Immunology, National Hospital Organization Nagoya Medical Center, Japan
Yoshiyuki Yokomaku
Infectious Diseases and Immunology, National Hospital Organization Nagoya Medical Center, Japan
Takashi Tokunaga
Department of Hematology, National Hospital Organization Nagoya Medical Center, Japan
Yasuhiko Miyata
Department of Hematology, National Hospital Organization Nagoya Medical Center, Japan
Hiroatsu Iida
Department of Hematology, National Hospital Organization Nagoya Medical Center, Japan
Hirokazu Nagai
Department of Hematology, National Hospital Organization Nagoya Medical Center, Japan

Keywords: acute promyelocytic leukemia, human immunodeficiency virus

JOURNAL OPEN ACCESS Advance online publication

Article ID: 1662-18

DOI https://doi.org/10.2169/internalmedicine.1662-18

The final version of this article is now available: Vol. 58 (2019), No. 16 pp. 2387-2391

Details

Abstract

Acute promyelocytic leukemia (APL) in human immunodeficiency virus (HIV)-infected individuals is very rare. There is currently no consensus regarding the use of anti-cancer drugs with highly active anti-retroviral therapy (ART) in these patients due to their small number. We herein report two cases of APL with HIV-infected patients. Both cases received all-trans-retinoic acid-containing chemotherapies and achieved complete remission. ART was continued throughout the treatment course. The clinical course of these cases suggests that it is preferable to perform standard chemotherapy for APL with ART if patients have an adequate performance status.

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