An Iron-chelating Agent Improved the Cardiac Function in a Patient with Severe Heart Failure Due to Hereditary Hemochromatosis

Akito Setoguchi; Hiroaki Kawano; Shinji Okano; Tomohiro Honda; Takeharu Kato; Sumito Dateki; Akira Senoo; Yomi Nakashima; Tetsufumi Motokawa; Yuki Ueno; Ryohei Akashi; Tsuyoshi Yonekura; Eijun Sueyoshi; Satoshi Ikeda; Yasushi Miyazaki; Koji Maemura

doi:10.2169/internalmedicine.1809-23

This article has now been updated. Please use the final version.

An Iron-chelating Agent Improved the Cardiac Function in a Patient with Severe Heart Failure Due to Hereditary Hemochromatosis

Akito Setoguchi, Hiroaki Kawano, Shinji Okano, Tomohiro Honda, Takeharu Kato, Sumito Dateki, Akira Senoo, Yomi Nakashima, Tetsufumi Motokawa, Yuki Ueno, Ryohei Akashi, Tsuyoshi Yonekura, Eijun Sueyoshi, Satoshi Ikeda, Yasushi Miyazaki, Koji Maemura

Author information

Akito Setoguchi
Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
Hiroaki Kawano
Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
Shinji Okano
Department of Pathology, Nagasaki University Hospital, Japan
Tomohiro Honda
Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
Takeharu Kato
Department of Hematology, Nagasaki University Graduate School of Biomedical Sciences, Japan
Sumito Dateki
Department of Pediatrics, Nagasaki University Graduate School of Biomedical Sciences, Japan
Akira Senoo
Division of Electron Microscopy, Pathology and Cytology Laboratories, Japan
Yomi Nakashima
Department of Endocrinology, Nagasaki University Graduate School of Biomedical Sciences, Japan
Tetsufumi Motokawa
Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
Yuki Ueno
Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
Ryohei Akashi
Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
Tsuyoshi Yonekura
Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
Eijun Sueyoshi
Department of Radiology, Nagasaki University Graduate School of Biomedical Sciences, Japan
Satoshi Ikeda
Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
Yasushi Miyazaki
Department of Hematology, Nagasaki University Graduate School of Biomedical Sciences, Japan
Koji Maemura
Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan

Keywords: iron overload, cardiomyopathy, tricuspid regurgitation

JOURNAL OPEN ACCESS Advance online publication

Article ID: 1809-23

DOI https://doi.org/10.2169/internalmedicine.1809-23

The final version of this article is now available: Vol. 63 (2024), No. 2 pp. 253-258

Details

Abstract

A 24-year-old man was admitted to our hospital because of severe heart failure. Although he was treated with diuretics and positive inotropic agents, his heart failure progressed. An endomyocardial biopsy revealed iron deposition in his myocytes. Finally, he was diagnosed with hereditary hemochromatosis. After starting administration of an iron-chelating agent in addition to conventional treatment for heart failure, his condition improved. We should consider hemochromatosis in heart failure patients with severe right ventricular dysfunction in addition to left ventricular dysfunction.

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