Renal Cell Carcinoma and Hepatocellular Carcinoma in a Patient with Wilson's Disease: A Case Report

Shogo Kitahata; Kojiro Michitaka; Miyuki Kinebuchi; Akihiro Matsuura; Atushi Hiraoka; Hideko Ohama; Emi Yanagihara; Hironobu Saneto; Hirofumi Izumoto; Tomoe Kawamura; Taira Kuroda; Fujimasa Tada; Hideki Miyata; Tomoyuki Ninomiya; Yoichi Hiasa

doi:10.2169/internalmedicine.2056-23

This article has now been updated. Please use the final version.

Renal Cell Carcinoma and Hepatocellular Carcinoma in a Patient with Wilson's Disease: A Case Report

Shogo Kitahata, Kojiro Michitaka, Miyuki Kinebuchi, Akihiro Matsuura, Atushi Hiraoka, Hideko Ohama, Emi Yanagihara, Hironobu Saneto, Hirofumi Izumoto, Tomoe Kawamura, Taira Kuroda, Fujimasa Tada, Hideki Miyata, Tomoyuki Ninomiya, Yoichi Hiasa

Author information

Shogo Kitahata
Gastroenterology Center, Ehime Prefectural Central Hospital, Japan
Kojiro Michitaka
Department of Internal Medicine, Saiseikai Imabari Dai2 Hospital, Japan
Miyuki Kinebuchi
First Department of Pathology, Sapporo Medical University, Japan
Akihiro Matsuura
Research Integrity Office, Fujita Health University, Japan
Atushi Hiraoka
Gastroenterology Center, Ehime Prefectural Central Hospital, Japan
Hideko Ohama
Gastroenterology Center, Ehime Prefectural Central Hospital, Japan
Emi Yanagihara
Gastroenterology Center, Ehime Prefectural Central Hospital, Japan
Hironobu Saneto
Gastroenterology Center, Ehime Prefectural Central Hospital, Japan
Hirofumi Izumoto
Gastroenterology Center, Ehime Prefectural Central Hospital, Japan
Tomoe Kawamura
Gastroenterology Center, Ehime Prefectural Central Hospital, Japan
Taira Kuroda
Gastroenterology Center, Ehime Prefectural Central Hospital, Japan
Fujimasa Tada
Gastroenterology Center, Ehime Prefectural Central Hospital, Japan
Hideki Miyata
Gastroenterology Center, Ehime Prefectural Central Hospital, Japan
Tomoyuki Ninomiya
Gastroenterology Center, Ehime Prefectural Central Hospital, Japan
Yoichi Hiasa
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan

Keywords: Wilson's disease, hepatocellular carcinoma, renal carcinoma, synchrotron X-ray (microbeam X-ray fluorescence)

JOURNAL OPEN ACCESS Advance online publication

Article ID: 2056-23

DOI https://doi.org/10.2169/internalmedicine.2056-23

The final version of this article is now available: Vol. 63 (2024), No. 7 pp. 963-968

Details

Abstract

No reports of renal cancer in patients with Wilson's disease (WD) exist. We herein report a 37-year-old Japanese man diagnosed with WD who had been treated with d-penicillamine 9 years prior. Hepatocellular carcinoma had been diagnosed at 36 years old and treated with radiofrequency ablation therapy. One year later, renal cancer and recurrent hepatocellular carcinoma had developed. The hepatocellular carcinoma was treated after renal cancer surgical resection of a clear-cell-type renal cell carcinoma, with iron, rather than copper, deposited on the renal cancer cells. This patient harbored a novel mutation, p. Leu1395Terfs in ATP7B.

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