Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918

This article has now been updated. Please use the final version.

Drug-induced Interstitial Nephritis in a Patient with Ulcerative Colitis Treated with 5-Aminosalicylic Acid: A Case Report
Daichi HayashiTsutomu NishidaNaoto OsugiYasuo KusunokiSatoru OkabeYoshifumi FujiiDai NakamatsuKengo MatsumotoMasashi YamamotoKoji Fukui
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JOURNAL OPEN ACCESS Advance online publication

Article ID: 2366-23

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Abstract

This report describes the case of a 76-year-old man with ulcerative colitis who developed interstitial nephritis after starting 5-aminosalicylic acid (5-ASA) therapy. The patient experienced an initial improvement in symptoms, but developed fatigue, anorexia, and severe renal dysfunction 2.5 months later. Renal biopsy confirmed drug-induced interstitial nephritis, and conservative treatment with fluid replacement and the discontinuation of 5-ASA improved the patient's condition. Clinicians should monitor patients receiving 5-ASA therapy for potential adverse effects, particularly renal injury, and promptly investigate symptoms of renal dysfunction. Early recognition and discontinuation of the offending agent may prevent further damage and improve patient outcomes.

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© 2023 by The Japanese Society of Internal Medicine
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