A Case of Primary IgA Vasculitis with Nephritis in a Patient with Rheumatoid Arthritis Diagnosed by Anti-galactose-deficient IgA1 Immunostaining

Kazunori Karasawa; Yuko Iwabuchi; Mizuki Kyoda; Taro Akihisa; Erika Yamaguchi; Shunji Suzuki; Shota Ogura; Tomo Takabe; Yoei Miyabe; Takahiro Kamiyama; Marie Nakano; Shun Manabe; Michiaki Kamiyama; Kenichi Akiyama; Masayo Sato; Keiko Uchida; Kosaku Nitta; Takahito Moriyama

doi:10.2169/internalmedicine.2640-19

This article has now been updated. Please use the final version.

A Case of Primary IgA Vasculitis with Nephritis in a Patient with Rheumatoid Arthritis Diagnosed by Anti-galactose-deficient IgA1 Immunostaining

Kazunori Karasawa, Yuko Iwabuchi, Mizuki Kyoda, Taro Akihisa, Erika Yamaguchi, Shunji Suzuki, Shota Ogura, Tomo Takabe, Yoei Miyabe, Takahiro Kamiyama, Marie Nakano, Shun Manabe, Michiaki Kamiyama, Kenichi Akiyama, Masayo Sato, Keiko Uchida, Kosaku Nitta, Takahito Moriyama

Author information

Kazunori Karasawa
Department of Nephrology, Tokyo Women's Medical University, Japan
Yuko Iwabuchi
Department of Nephrology, Tokyo Women's Medical University, Japan
Mizuki Kyoda
Department of Nephrology, Tokyo Women's Medical University, Japan
Taro Akihisa
Department of Nephrology, Tokyo Women's Medical University, Japan
Erika Yamaguchi
Department of Nephrology, Tokyo Women's Medical University, Japan
Shunji Suzuki
Department of Nephrology, Tokyo Women's Medical University, Japan
Shota Ogura
Department of Nephrology, Tokyo Women's Medical University, Japan
Tomo Takabe
Department of Nephrology, Tokyo Women's Medical University, Japan
Yoei Miyabe
Department of Nephrology, Tokyo Women's Medical University, Japan
Takahiro Kamiyama
Department of Nephrology, Tokyo Women's Medical University, Japan
Marie Nakano
Department of Nephrology, Tokyo Women's Medical University, Japan
Shun Manabe
Department of Nephrology, Tokyo Women's Medical University, Japan
Michiaki Kamiyama
Department of Nephrology, Tokyo Women's Medical University, Japan
Kenichi Akiyama
Department of Nephrology, Tokyo Women's Medical University, Japan
Masayo Sato
Department of Nephrology, Tokyo Women's Medical University, Japan
Keiko Uchida
Department of Nephrology, Tokyo Women's Medical University, Japan
Kosaku Nitta
Department of Nephrology, Tokyo Women's Medical University, Japan
Takahito Moriyama
Department of Nephrology, Tokyo Women's Medical University, Japan

Keywords: IgA vasculitis with nephritis, anti-galactose-deficient IgA1 antibody, nephrotic syndrome, rheumatoid arthritis

JOURNAL OPEN ACCESS Advance online publication

Article ID: 2640-19

DOI https://doi.org/10.2169/internalmedicine.2640-19

The final version of this article is now available: Vol. 58 (2019), No. 17 pp. 2551-2554

Details

Abstract

Renal disease is a common complication of rheumatoid arthritis (RA) and can occur secondary to RA or be induced by therapeutic agents. Recently, glomerular deposition of galactose-deficient IgA1 (Gd-IgA1) was identified as a feature of primary IgA vasculitis with nephritis (IgA-VN). We herein report a case of IgA-VN in an RA patient whose disease activity was controlled by treatment with etanercept. To distinguish between primary IgA-VN and secondary IgA-VN caused by RA or etanercept, we performed immunostaining of renal biopsy sections with the Gd-IgA1-specific antibody KM55. Positive KM55 staining confirmed the diagnosis of primary IgA-VN in a patient with RA.

Corresponding author

Register with J-STAGE for free!