A Case of Solitary Pure Ground-glass Opacity Suspected of Being the Initial Presentation of Nonfibrotic Hypersensitivity Pneumonitis

Natsushi Kubota; Tsukasa Okamoto; Sho Shimada; Takashi Yamana; Yuki Iijima; Rie Sakakibara; Sho Shibata; Takayuki Honda; Takahiro Mitsumura; Tsuyoshi Shirai; Haruhiko Furusawa; Tomoya Tateishi; Takuya Adachi; Susumu Kirimura; Yasunari Miyazaki

doi:10.2169/internalmedicine.3030-23

This article has now been updated. Please use the final version.

A Case of Solitary Pure Ground-glass Opacity Suspected of Being the Initial Presentation of Nonfibrotic Hypersensitivity Pneumonitis

Natsushi Kubota, Tsukasa Okamoto, Sho Shimada, Takashi Yamana, Yuki Iijima, Rie Sakakibara, Sho Shibata, Takayuki Honda, Takahiro Mitsumura, Tsuyoshi Shirai, Haruhiko Furusawa, Tomoya Tateishi, Takuya Adachi, Susumu Kirimura, Yasunari Miyazaki

Author information

Natsushi Kubota
Department of Respiratory Medicine, Tokyo Medical and Dental University, Japan
Department of Respiratory Medicine, Musashino Red Cross Hospital, Japan
Tsukasa Okamoto
Department of Respiratory Medicine, Tokyo Medical and Dental University, Japan
Center for Personalized Medicine for Healthy Aging, Tokyo Medical and Dental University, Japan
Sho Shimada
Department of Respiratory Medicine, Tokyo Medical and Dental University, Japan
Takashi Yamana
Department of Respiratory Medicine, Tokyo Medical and Dental University, Japan
Yuki Iijima
Department of Respiratory Medicine, Tokyo Medical and Dental University, Japan
Rie Sakakibara
Department of Respiratory Medicine, Tokyo Medical and Dental University, Japan
Sho Shibata
Department of Respiratory Medicine, Tokyo Medical and Dental University, Japan
Takayuki Honda
Department of Respiratory Medicine, Tokyo Medical and Dental University, Japan
Takahiro Mitsumura
Department of Respiratory Medicine, Tokyo Medical and Dental University, Japan
Tsuyoshi Shirai
Department of Respiratory Medicine, Tokyo Medical and Dental University, Japan
Haruhiko Furusawa
Department of Respiratory Medicine, Tokyo Medical and Dental University, Japan
Tomoya Tateishi
Department of Respiratory Medicine, Tokyo Medical and Dental University, Japan
Takuya Adachi
Department of Diagnostic Radiology, Tokyo Medical and Dental University, Japan
Susumu Kirimura
Department of Pathology, Tokyo Medical and Dental University, Japan
Yasunari Miyazaki
Department of Respiratory Medicine, Tokyo Medical and Dental University, Japan

Keywords: hypersensitivity pneumonitis, ground-glass opacity, antigen avoidance, centrilobular nodule

JOURNAL OPEN ACCESS Advance online publication

Article ID: 3030-23

DOI https://doi.org/10.2169/internalmedicine.3030-23

The final version of this article is now available: Vol. 63 (2024), No. 18 pp. 2543-2546

Details

Abstract

We herein report a rare case of hypersensitivity pneumonitis (HP) that was initially demonstrated as solitary pure ground-glass opacity (GGO) on chest computed tomography (CT). A 51-year-old woman with a history of breast cancer underwent follow-up CT, which revealed solitary pure GGO. The patient developed exertional dyspnea after two years, and CT revealed diffuse centrilobular nodules in addition to GGO, which had increased in size. An antigen avoidance test was performed to diagnose HP, leading to the resolution of CT abnormalities, including the GGO. Our findings suggested that nonfibrotic HP can present as solitary pure GGO.

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