Kluyvera georgiana Bacteremia Due to Acute Cholangitis: A Report of the First Known Case and a Literature Review

Go Endo; Sachiko Kanai; Hiroto Nishio; Hideki Hashimoto; Yoshimi Higurashi; Yusuke Nomura; Yousuke Nakai; Mitsuhiro Fujishiro

doi:10.2169/internalmedicine.3036-23

Kluyvera georgiana Bacteremia Due to Acute Cholangitis: A Report of the First Known Case and a Literature Review

Go Endo, Sachiko Kanai, Hiroto Nishio, Hideki Hashimoto, Yoshimi Higurashi, Yusuke Nomura, Yousuke Nakai, Mitsuhiro Fujishiro

Author information

Go Endo
Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Japan
Sachiko Kanai
Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Japan
Department of Endoscopy and Endoscopic Surgery, The University of Tokyo Hospital, Japan
Hiroto Nishio
Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Japan
Hideki Hashimoto
Department of Infectious Diseases, Graduate School of Medicine, The University of Tokyo Hospital, Japan
Yoshimi Higurashi
Department of Infection Control and Prevention, The University of Tokyo Hospital, Japan
Yusuke Nomura
Department of Infection Control and Prevention, The University of Tokyo Hospital, Japan
Yousuke Nakai
Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Japan
Department of Endoscopy and Endoscopic Surgery, The University of Tokyo Hospital, Japan
Mitsuhiro Fujishiro
Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Japan

Keywords: Kluyvera georgiana, Bacteremia, Cholangitis

JOURNAL OPEN ACCESS Advance online publication

Article ID: 3036-23

DOI https://doi.org/10.2169/internalmedicine.3036-23

Details

Abstract

We herein present the first known case of bacteremia caused by Kluyvera georgiana in a 67-year-old female undergoing chemotherapy for recurrent pancreatic cancer. The patient underwent choledochojejunotomy and thereafter developed ascending cholangitis. The diagnosis of K. georgiana was confirmed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. A literature review of Kluyvera spp. infections indicated potential risk factors including an underlying malignancy and immunosuppression. Although Kluyvera spp. infections are typically sensitive to antibiotics, multidrug resistance is possible. This case highlights the importance of the early diagnosis and treatment of K. georgiana and its associated risk factors.

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