Dapagliflozin-induced drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Followed By Acute Interstitial Nephritis (AIN): A Case Report

Tomohisa Tsuyuki; Kenta Torigoe; Masatoshi Shimizu; Hiroshi Taira; Ryosuke Sakamoto; Shinichi Abe; Sayaka Kuwatsuka; Kumiko Muta; Hiroshi Mukae; Tomoya Nishino

doi:10.2169/internalmedicine.3347-23

This article has now been updated. Please use the final version.

Dapagliflozin-induced drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Followed By Acute Interstitial Nephritis (AIN): A Case Report

Tomohisa Tsuyuki, Kenta Torigoe, Masatoshi Shimizu, Hiroshi Taira, Ryosuke Sakamoto, Shinichi Abe, Sayaka Kuwatsuka, Kumiko Muta, Hiroshi Mukae, Tomoya Nishino

Author information

Tomohisa Tsuyuki
Department of Nephrology, Nagasaki University Hospital, Japan
Kenta Torigoe
Department of Nephrology, Nagasaki University Hospital, Japan
Masatoshi Shimizu
Department of Nephrology, Nagasaki University Hospital, Japan
Hiroshi Taira
Department of Nephrology, Nagasaki University Hospital, Japan
Ryosuke Sakamoto
Department of Nephrology, Nagasaki University Hospital, Japan
Shinichi Abe
Department of Nephrology, Nagasaki University Hospital, Japan
Sayaka Kuwatsuka
Department of Dermatology, Nagasaki University Hospital, Japan
Kumiko Muta
Department of Nephrology, Nagasaki University Hospital, Japan
Hiroshi Mukae
Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
Tomoya Nishino
Department of Nephrology, Nagasaki University Hospital, Japan

Keywords: Sodium-glucose cotransporter 2 inhibitors, Acute interstitial nephritis, Drug reaction with eosinophilia and systemic symptoms, Drug hypersensitivity

JOURNAL OPEN ACCESS Advance online publication

Article ID: 3347-23

DOI https://doi.org/10.2169/internalmedicine.3347-23

The final version of this article is now available: Vol. 63 (2024), No. 23 pp. 3203-3208

Details

Abstract

A 78-year-old male was admitted to the hospital with acute renal failure and generalized erythema after starting dapagliflozin 10 mg/day for chronic kidney disease (CKD). A skin biopsy revealed superficial perivascular dermatitis with eosinophils. A renal biopsy revealed lymphocytic and eosinophilic infiltration of the interstitium, and focal tubulitis. The patient was diagnosed with a dapagliflozin-induced drug reaction with eosinophilia and systemic symptoms (DRESS), followed by acute interstitial nephritis (AIN), and prednisolone therapy was therefore initiated. The patient's renal function improved, and erythema disappeared. To our knowledge, this is the first report of DRESS caused by dapagliflozin, and the patient was successfully treated with prednisolone.

Corresponding author

Register with J-STAGE for free!