Glut-1-Negative Choroidal Malignant Melanoma with Liver Metastasis Recurrence 12 Years after Surgery without FDG Accumulation in a Recurrent Lesion on FDG-PET/CT: a Case Report

Toyoki Shimamoto; Hironori Ochi; Cao Fang; Michiko Amano; Takaaki Tanaka; Nobuaki Azemoto; Toshie Mashiba; Koichi Kimura; Ryosuke Minagawa; Yumi Ooshiro; Toshio Kodama; Tomoyuki Yokota

doi:10.2169/internalmedicine.4204-24

This article has now been updated. Please use the final version.

Glut-1-Negative Choroidal Malignant Melanoma with Liver Metastasis Recurrence 12 Years after Surgery without FDG Accumulation in a Recurrent Lesion on FDG-PET/CT: a Case Report

Toyoki Shimamoto, Hironori Ochi, Cao Fang, Michiko Amano, Takaaki Tanaka, Nobuaki Azemoto, Toshie Mashiba, Koichi Kimura, Ryosuke Minagawa, Yumi Ooshiro, Toshio Kodama, Tomoyuki Yokota

Author information

Toyoki Shimamoto
Department of Liver-Biliary-Pancreatic Disease, Matsuyama Red Cross Hospital, Japan
Hironori Ochi
Department of Liver-Biliary-Pancreatic Disease, Matsuyama Red Cross Hospital, Japan
Cao Fang
Department of Liver-Biliary-Pancreatic Disease, Matsuyama Red Cross Hospital, Japan
Michiko Amano
Department of Liver-Biliary-Pancreatic Disease, Matsuyama Red Cross Hospital, Japan
Takaaki Tanaka
Department of Liver-Biliary-Pancreatic Disease, Matsuyama Red Cross Hospital, Japan
Nobuaki Azemoto
Department of Liver-Biliary-Pancreatic Disease, Matsuyama Red Cross Hospital, Japan
Toshie Mashiba
Department of Liver-Biliary-Pancreatic Disease, Matsuyama Red Cross Hospital, Japan
Koichi Kimura
Department of Surgery, Matsuyama Red Cross Hospital, Japan
Ryosuke Minagawa
Department of Surgery, Matsuyama Red Cross Hospital, Japan
Yumi Ooshiro
Department of Pathology, Matsuyama Red Cross Hospital, Japan
Toshio Kodama
Department of Ophthalmology, Matsuyama Red Cross Hospital, Japan
Tomoyuki Yokota
Department of Liver-Biliary-Pancreatic Disease, Matsuyama Red Cross Hospital, Japan

Keywords: choroidal malignant melanoma, metastatic liver tumor, PET/CT

JOURNAL OPEN ACCESS Advance online publication

Article ID: 4204-24

DOI https://doi.org/10.2169/internalmedicine.4204-24

The final version of this article is now available: Vol. 64 (2025), No. 9 pp. 1327-1333

Details

Abstract

Choroidal malignant melanoma is a rare malignant tumor that develops in adult eyeballs. It causes early lymph node and distant metastasis. Fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (CT) is widely used for screening malignant melanoma metastases. We encountered a 58-year-old man with choroidal malignant melanoma in whom liver metastasis recurred 12 years after surgery, without any observable FDG accumulation. Immunostaining revealed the absence of glucose transporter type 1 (GLUT-1) expression, crucial for intracellular FDG uptake. The lack of FDG accumulation in the lesion could be attributed to the diminished cellular FDG uptake due to the absence of GLUT-1 expression.

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