Monomicrobial Fournier's gangrene caused by Panton-Valentine leukocidin-negative methicillin-susceptible Staphylococcus aureus ST8 in Japan: A case report

Hirofumi Yamagishi; Kenichi Kawahori; Noriaki Ohkiba; Nozomi Murooka; Takeshi Inazawa

doi:10.2169/internalmedicine.4334-19

This article has now been updated. Please use the final version.

Monomicrobial Fournier's gangrene caused by Panton-Valentine leukocidin-negative methicillin-susceptible Staphylococcus aureus ST8 in Japan: A case report

Hirofumi Yamagishi, Kenichi Kawahori, Noriaki Ohkiba, Nozomi Murooka, Takeshi Inazawa

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Keywords: Fournier's gangrene, methicillin-susceptible Staphylococcus aureus ST8, Panton-Valentine leukocidin, toxic shock syndrome toxin-1

JOURNAL OPEN ACCESS Advance online publication

Article ID: 4334-19

DOI https://doi.org/10.2169/internalmedicine.4334-19

The final version of this article is now available: Vol. 59 (2020), No. 14 pp. 1769-1772

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Abstract

Methicillin-resistant Staphylococcus aureus USA300, belonging to sequence type (ST) 8, is a rare cause of necrotizing fasciitis in the USA. We herein report a case of monomicrobial Fournier's gangrene caused by an ST8, methicillin-susceptible Staphylococcus aureus (designated ksw1). Whole-genome sequencing and analyses for virulence determinants revealed that, unlike USA300, ksw1 lacked virulence genes, such as Panton-Valentine leukocidin and SCCmec, while harboring the toxic shock syndrome toxin-1 gene. These genomic features correlate with ST8 CA-MRSA/J, which is the major genotype of ST8 in Japan.

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