Successful Therapy Using Pasireotide Long-acting Release for Cushing's Disease Merged with Biochemical Acromegaly

Kensaku Fukunaga; Hitomi Imachi; Seisuke Sato; Toshihiro Kobayashi; Yuki Yoshioka; Takanobu Saheki; Natsuki Ban; Kurumi Urushihara; Jingya Lyu; Tao Dong; Ryou Ishikawa; Kyuichi Kadota; Reiji Haba; Naoko Inoshita; Koji Murao

doi:10.2169/internalmedicine.4663-20

This article has now been updated. Please use the final version.

Successful Therapy Using Pasireotide Long-acting Release for Cushing's Disease Merged with Biochemical Acromegaly

Kensaku Fukunaga, Hitomi Imachi, Seisuke Sato, Toshihiro Kobayashi, Yuki Yoshioka, Takanobu Saheki, Natsuki Ban, Kurumi Urushihara, Jingya Lyu, Tao Dong, Ryou Ishikawa, Kyuichi Kadota, Reiji Haba, Naoko Inoshita, Koji Murao

Author information

Kensaku Fukunaga
Department of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Japan
Hitomi Imachi
Department of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Japan
Seisuke Sato
Department of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Japan
Toshihiro Kobayashi
Department of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Japan
Yuki Yoshioka
Department of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Japan
Takanobu Saheki
Department of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Japan
Natsuki Ban
Department of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Japan
Kurumi Urushihara
Department of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Japan
Jingya Lyu
Department of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Japan
Tao Dong
Department of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Japan
Ryou Ishikawa
Department of Diagnostic Pathology, Faculty of Medicine, Kagawa University, Japan
Kyuichi Kadota
Department of Diagnostic Pathology, Faculty of Medicine, Kagawa University, Japan
Reiji Haba
Department of Diagnostic Pathology, Faculty of Medicine, Kagawa University, Japan
Naoko Inoshita
Department of Pathology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Japan
Koji Murao
Department of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Japan

Keywords: Acromegaly, Cushing's disease, pasireotide long-acting release (LAR), somatostatin analog, plurihormonal pituitary adenoma

JOURNAL OPEN ACCESS Advance online publication

Article ID: 4663-20

DOI https://doi.org/10.2169/internalmedicine.4663-20

The final version of this article is now available: Vol. 60 (2021), No. 7 pp. 1047-1053

Details

Abstract

It is quite rare that Cushing's disease shows acromegaly, and no pharmacotherapy has yet been discussed. A 21-year-old woman was diagnosed with Cushing's disease and underwent trans-sphenoidal surgery. Five years later, she was diagnosed with recurrent Cushing's disease and biochemical acromegaly because of elevated levels of serum growth hormone (GH), plasma insulin-like growth factor-1, plasma adrenocorticotropic hormone (ACTH), and the 24-h urinary excretion of free cortisol. After treatment initiation with pasireotide-long-acting release (LAR), both the ACTH and GH declined. Our case is the first to show the efficacy of pasireotide-LAR in controlling both Cushing's disease and acromegaly.

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