Successful Allogeneic Hematopoietic Stem Cell Transplantation for Nodal Epstein-Barr Virus-positive T/NK-cell Lymphoma

Satoshi Ichikawa; Hiroaki Abe; Naoya Morota; Akihisa Kawajiri; Ryo Nakagawa; Kyoko Inokura; Shunsuke Hatta; Yuna Katsuoka; Koichi Onodera; Noriko Fukuhara; Yasushi Onishi; Hisayuki Yokoyama; Ryo Ichinohasama; Hideo Harigae

doi:10.2169/internalmedicine.4672-24

Satoshi Ichikawa, Hiroaki Abe, Naoya Morota, Akihisa Kawajiri, Ryo Nakagawa, Kyoko Inokura, Shunsuke Hatta, Yuna Katsuoka, Koichi Onodera, Noriko Fukuhara, Yasushi Onishi, Hisayuki Yokoyama, Ryo Ichinohasama, Hideo Harigae

Author information

Satoshi Ichikawa
Department of Hematology, Tohoku University Hospital, Japan
Division of Hematology and Rheumatology, Tohoku Medical and Pharmaceutical University, Japan
Hiroaki Abe
Department of Hematology, Tohoku University Hospital, Japan
Naoya Morota
Department of Hematology, Tohoku University Hospital, Japan
Akihisa Kawajiri
Department of Hematology, Tohoku University Hospital, Japan
Ryo Nakagawa
Department of Hematology, Tohoku University Hospital, Japan
Kyoko Inokura
Department of Hematology, Tohoku University Hospital, Japan
Shunsuke Hatta
Department of Hematology, Tohoku University Hospital, Japan
Department of Hematology, Sendai Medical Center, Japan
Yuna Katsuoka
Department of Hematology, Sendai Medical Center, Japan
Koichi Onodera
Department of Hematology, Tohoku University Hospital, Japan
Noriko Fukuhara
Department of Hematology, Tohoku University Hospital, Japan
Yasushi Onishi
Department of Hematology, Tohoku University Hospital, Japan
Hisayuki Yokoyama
Department of Hematology, Tohoku University Hospital, Japan
Department of Hematology, Yamagata University Hospital, Japan
Ryo Ichinohasama
Department of Hematopathology, Tohoku University Hospital, Japan
Hideo Harigae
Department of Hematology, Tohoku University Hospital, Japan

Keywords: Epstein-Barr virus-positive T/NK-cell tumors, nodal Epstein-Barr virus-positive T/NK-cell lymphoma, allogeneic hematopoietic stem cell transplantation, L-asparaginase

JOURNAL OPEN ACCESS Advance online publication

Article ID: 4672-24

DOI https://doi.org/10.2169/internalmedicine.4672-24

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Abstract

Nodal Epstein-Barr virus-positive T/NK-cell lymphoma (EB-nTNKL) is an extremely rare disease characterized by an aggressive clinical course and poor prognosis, for which treatment strategies have not yet been established. We herein report a young man with EB-nTNKL. Although initial chemotherapies, including L-asparaginase, failed to produce a good response, subsequent myeloablative allogeneic hematopoietic stem cell transplantation (alloHSCT) resulted in favorable disease control and a long-term disease-free survival. The prompt performance of alloHSCT using an available donor source at that time, regardless of whether or not the initial chemotherapy was effective, could be critical to saving patients with this otherwise fatal disease.

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