Unrelated Bone Marrow Transplantation for Chronic Myeloid Leukemia after Liver Transplantation

Mirea Watanabe; Atsushi Marumo; Daishi Onai; Meya Li; Yuta Kaito; Toshio Asayama; Shunsuke Yui; Yasunobu Nagata; Satoshi Wakita; Hiroki Yamaguchi

doi:10.2169/internalmedicine.4759-24

Mirea Watanabe, Atsushi Marumo, Daishi Onai, Meya Li, Yuta Kaito, Toshio Asayama, Shunsuke Yui, Yasunobu Nagata, Satoshi Wakita, Hiroki Yamaguchi

Author information

Mirea Watanabe
Department of Hematology, Nippon Medical School, Japan
Atsushi Marumo
Department of Hematology, Nippon Medical School, Japan
Daishi Onai
Department of Hematology, Nippon Medical School, Japan
Meya Li
Department of Hematology, Nippon Medical School, Japan
Yuta Kaito
Department of Hematology, Nippon Medical School, Japan
Toshio Asayama
Department of Hematology, Nippon Medical School, Japan
Shunsuke Yui
Department of Hematology, Nippon Medical School, Japan
Yasunobu Nagata
Department of Hematology, Nippon Medical School, Japan
Satoshi Wakita
Department of Hematology, Nippon Medical School, Japan
Hiroki Yamaguchi
Department of Hematology, Nippon Medical School, Japan

Keywords: hematopoietic stem cell transplantation, liver transplantation, chronic myeloid leukemia, liver dysfunction, post-transplant-related complications

JOURNAL OPEN ACCESS Advance online publication

Article ID: 4759-24

DOI https://doi.org/10.2169/internalmedicine.4759-24

Details

Abstract

This report describes the case of a 29-year-old patient with chronic myeloid leukemia in the blast phase who underwent hematopoietic stem cell transplantation (HSCT) after living-donor liver transplantation. Donor selection, conditioning regimens, and graft-versus-host disease (GVHD) prophylaxis are discussed. The patient received a non-myeloablative conditioning regimen and ABO blood group-matched unrelated human leukocyte antigen fully-matched donors. Immunosuppressants tacrolimus and mycophenolate mofetil were administered to prevent GVHD. Maintenance therapy with ponatinib effectively maintained remission. This case highlights the complexities of managing HSCT after solid organ transplantation and suggests strategies for future cases.

Corresponding author

Register with J-STAGE for free!