Isolated Atrial Amyloidosis in a Patient with Aortic Regurgitation and Paroxysmal Atrial Fibrillation

Hiroaki Kawano; Nozomi Ueki; Akira Senoo; Ichiro Matsumaru; Chikara Ohno; Tsuyoshi Yoshimuta; Takashi Miura; Mitsuaki Ueda; Takashi Kudo; Masahiro Nakashima; Koji Maemura

doi:10.2169/internalmedicine.5049-24

Hiroaki Kawano, Nozomi Ueki, Akira Senoo, Ichiro Matsumaru, Chikara Ohno, Tsuyoshi Yoshimuta, Takashi Miura, Mitsuaki Ueda, Takashi Kudo, Masahiro Nakashima, Koji Maemura

Author information

Hiroaki Kawano
Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
Nozomi Ueki
Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Japan
Akira Senoo
Division of Electron Microscopy, Pathology and Cytology Laboratories, Japan
Ichiro Matsumaru
Department of Cardiovascular Surgery, Nagasaki University Graduate School of Biomedical Sciences, Japan
Chikara Ohno
Ultrasound Imaging Center, Nagasaki University Hospital, Japan
Tsuyoshi Yoshimuta
Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
Takashi Miura
Department of Cardiovascular Surgery, Nagasaki University Graduate School of Biomedical Sciences, Japan
Mitsuaki Ueda
Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Japan
Takashi Kudo
Department of Radioisotope Medicine, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University, Japan
Masahiro Nakashima
Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Japan
Koji Maemura
Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan

Keywords: amyloidosis, arrhythmia, heart failure

JOURNAL OPEN ACCESS Advance online publication

Article ID: 5049-24

DOI https://doi.org/10.2169/internalmedicine.5049-24

Details

Abstract

A 65-year-old woman was admitted to our hospital with heart failure secondary to aortic regurgitation and paroxysmal atrial fibrillation. During surgery for valve-sparing aortic root replacement, a biopsy was obtained from the right atrium because of paroxysmal AF and mild LV hypokinesis. A histopathological examination revealed atrial natriuretic peptide amyloidosis, and the patient was clinically diagnosed with isolated atrial amyloidosis (IAA). Although IAA is rarely diagnosed clinically, it should be considered in patients with AF and heart failure.

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