An autopsy for persistent coronavirus disease 2019 pneumonia during follicular lymphoma treatment: A case report

Hikaru Mamizu; Jun Tsuji; Morihiro Kumagai; Chika Kuwana; Masanori Miyagatani; Maiko Mamizu; Daisuke Ishikawa; Hidenori Kawakami; Toshiki Furukawa; Takashi Ishida; Chizuru Kaneko; Takeshi Sakai

doi:10.2169/internalmedicine.5283-25

Hikaru Mamizu, Jun Tsuji, Morihiro Kumagai, Chika Kuwana, Masanori Miyagatani, Maiko Mamizu, Daisuke Ishikawa, Hidenori Kawakami, Toshiki Furukawa, Takashi Ishida, Chizuru Kaneko, Takeshi Sakai

Author information

Hikaru Mamizu
Department of Internal Medicine, Niigata Prefectural Central Hospital, Japan
Jun Tsuji
Department of Internal Medicine, Niigata Prefectural Central Hospital, Japan
Morihiro Kumagai
Department of Internal Medicine, Niigata Prefectural Central Hospital, Japan
Chika Kuwana
Department of Internal Medicine, Niigata Prefectural Central Hospital, Japan
Masanori Miyagatani
Department of Internal Medicine, Niigata Prefectural Central Hospital, Japan
Maiko Mamizu
Department of Internal Medicine, Niigata Prefectural Central Hospital, Japan
Daisuke Ishikawa
Department of Internal Medicine, Niigata Prefectural Central Hospital, Japan
Hidenori Kawakami
Department of Internal Medicine, Niigata Prefectural Central Hospital, Japan
Toshiki Furukawa
Department of Internal Medicine, Niigata Prefectural Central Hospital, Japan
Takashi Ishida
Department of Internal Medicine, Niigata Prefectural Central Hospital, Japan
Chizuru Kaneko
Department of Diagnostic Pathology, Niigata Prefectural Central Hospital, Japan
Takeshi Sakai
Department of Diagnostic Pathology, Niigata Prefectural Central Hospital, Japan

Keywords: severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), coronavirus disease 2019 (COVID-19), follicular lymphoma, obinutuzumab, bendamustine

JOURNAL OPEN ACCESS Advance online publication

Article ID: 5283-25

DOI https://doi.org/10.2169/internalmedicine.5283-25

Details

Abstract

A 66-year-old man who was receiving treatment for B-cell non-Hodgkin lymphoma presented with fever. He tested positive for severe acute respiratory syndrome coronavirus 2 antigen. Chest computed tomography (CT) revealed pneumonia. Therefore, remdesivir was administered to the patient. However, steroid pulse therapy was initiated owing to the lack of any symptom improvement and a worsening of the CT findings. The patient developed recurrent fever following a reduction in the steroid dose. His respiratory condition gradually worsened, and he eventually died. Autopsy revealed diffuse alveolar damage. In high-risk patients with hematologic malignancy, COVID-19 vaccination should be repeated at shorter intervals to avoid increasing the viral load during the COVID-19 infection.

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