Continuously High Titers of Multiple Islet-associated Autoantibodies in an Individual with an Elderly Onset of Type 1 Diabetes Mellitus and Basedow's Disease: A Case Report with a Review of Literature

Abstract

In cases of the elderly onset of type 1 diabetes mellitus (T1DM), multiple islet-associated autoantibodies tend to be less prevalent with increasing age at the diagnosis. In addition, the titers of various islet-associated autoantibodies decrease and often disappear within several years, according to the increasing duration of diabetes. A few reports have described the titers of various islet-associated autoantibodies in cases of the elderly onset of T1DM and Basedow's disease. We herein report an elderly patient with a T1DM onset under poorly controlled Basedow's disease, wherein the titers of various islet-associated autoantibodies remained very high for over five years.