The Usefulness of a Transbronchial Lung Cryobiopsy for Diffuse Bronchiolitis

Hideaki Yamakawa; Tamiko Takemura; Shintaro Sato; Tomohiko Nakamura; Tomotaka Nishizawa; Tomohiro Oba; Rie Kawabe; Keiichi Akasaka; Masako Amano; Kazuyoshi Kuwano; Hidekazu Matsushima

doi:10.2169/internalmedicine.6028-20

This article has now been updated. Please use the final version.

The Usefulness of a Transbronchial Lung Cryobiopsy for Diffuse Bronchiolitis

Hideaki Yamakawa, Tamiko Takemura, Shintaro Sato, Tomohiko Nakamura, Tomotaka Nishizawa, Tomohiro Oba, Rie Kawabe, Keiichi Akasaka, Masako Amano, Kazuyoshi Kuwano, Hidekazu Matsushima

Author information

Hideaki Yamakawa
Department of Respiratory Medicine, Saitama Red Cross Hospital, Japan
Department of Respiratory Medicine, Tokyo Jikei University Hospital, Japan
Tamiko Takemura
Department of Pathology, Kanagawa Cardiovascular and Respiratory Center, Japan
Shintaro Sato
Department of Respiratory Medicine, Saitama Red Cross Hospital, Japan
Tomohiko Nakamura
Department of Respiratory Medicine, Saitama Red Cross Hospital, Japan
Tomotaka Nishizawa
Department of Respiratory Medicine, Saitama Red Cross Hospital, Japan
Tomohiro Oba
Department of Respiratory Medicine, Saitama Red Cross Hospital, Japan
Rie Kawabe
Department of Respiratory Medicine, Saitama Red Cross Hospital, Japan
Keiichi Akasaka
Department of Respiratory Medicine, Saitama Red Cross Hospital, Japan
Masako Amano
Department of Respiratory Medicine, Saitama Red Cross Hospital, Japan
Kazuyoshi Kuwano
Department of Respiratory Medicine, Tokyo Jikei University Hospital, Japan
Hidekazu Matsushima
Department of Respiratory Medicine, Saitama Red Cross Hospital, Japan

Keywords: Transbronchial lung cryobiopsy, Diffuse panbronchiolitis, Primary ciliary dyskinesia, Constrictive bronchiolitis

JOURNAL OPEN ACCESS Advance online publication

Article ID: 6028-20

DOI https://doi.org/10.2169/internalmedicine.6028-20

The final version of this article is now available: Vol. 60 (2021), No. 9 pp. 1457-1462

Details

Abstract

We herein report four cases of diffuse bronchiolitis proven by a transbronchial lung cryobiopsy (TBLC). Based on various aspects, including the pathological findings, we definitively diagnosed two patients with diffuse panbronchiolitis (DPB) and the other two with primary ciliary dyskinesia (PCD). One of the DPB patients had more severe peribronchiolar fibrosis than the other, and the disease course was refractory to macrolide therapy. One of the PCD patients was additionally diagnosed with combined constrictive bronchiolitis. This report highlights the importance of a TBLC in the differentiation of bronchiolitis, suggesting its utility for helping pulmonologists formulate a treatment strategy.

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