Acute Pulmonary Graft-Versus-Host Disease in a Patient with Adult T-cell Leukemia-Lymphoma Diagnosed by a Cryobiopsy

Hiroshi Kobe; Machiko Arita; Takeshi Maeda; Osamu Nagata; Takashi Niwa; Fumiaki Tokioka; Tadashi Ishida

doi:10.2169/internalmedicine.6358-20

This article has now been updated. Please use the final version.

Acute Pulmonary Graft-Versus-Host Disease in a Patient with Adult T-cell Leukemia-Lymphoma Diagnosed by a Cryobiopsy

Hiroshi Kobe, Machiko Arita, Takeshi Maeda, Osamu Nagata, Takashi Niwa, Fumiaki Tokioka, Tadashi Ishida

Author information

Keywords: adult T-cell leukemia-lymphoma, transbronchial lung cryobiopsy, acute graft-versus-host disease, spontaneous remission

JOURNAL OPEN ACCESS Advance online publication

Article ID: 6358-20

DOI https://doi.org/10.2169/internalmedicine.6358-20

The final version of this article is now available: Vol. 60 (2021), No. 14 pp. 2269-2273

Details

Abstract

A 51-year-old woman with adult T-cell leukemia-lymphoma was hospitalized in order to undergo allogeneic hematopoietic stem cell transplantation. On day 29 after transplantation, she began to experience hypoxia upon exertion. Chest computed tomography revealed centrilobular granular shadows, and pulmonary function tests revealed a remarkable obstructive ventilatory impairment compared to before transplantation. A histopathological analysis following a transbronchial lung cryobiopsy revealed acute graft-versus-host disease (GVHD). We herein report a rare case of histopathologically diagnosed acute pulmonary GVHD with spontaneous remission.

Corresponding author

Register with J-STAGE for free!