Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918

This article has now been updated. Please use the final version.

Correction of Hypercortisolemia with an Improved Cognitive Function and Muscle Mass after Transsphenoidal Surgery in an Older Patient with Cushing's Disease: A Case Report
Ryo TerayamaTakahiro IshikawaKazuki IshiwataAi SatoTakuya MinamizukaTomohiro OhnoSatomi KonoMasashi YamamotoHidetaka YokohHidekazu NaganoMasaya KoshizakaSawako SuzukiHisashi KoideYoshiro MaezawaKoutaro Yokote
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JOURNAL OPEN ACCESS Advance online publication

Article ID: 8326-21


Cushing's disease causes numerous metabolic disorders, cognitive decline, and sarcopenia, leading to deterioration of the general health in older individuals. Cushing's disease can be treated with transsphenoidal surgery, but thus far, surgery has often been avoided in older patients. We herein report an older woman with Cushing's disease whose cognitive impairment and sarcopenia improved after transsphenoidal surgery. Although cognitive impairment and sarcopenia in most older patients show resistance to treatment, our case indicates that normalization of the cortisol level by transsphenoidal surgery can be effective in improving the cognitive impairment and muscle mass loss caused by Cushing's disease.

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