Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918

This article has now been updated. Please use the final version.

Ceftriaxone-induced Neurotoxicity in a Patient after Pancreas-Kidney Transplantation
Hideharu HagiyaKoji MiyawakiNorihisa YamamotoHisao YoshidaAkihiro KitagawaTadafumi AsaokaHidetoshi EguchiYukihiro AkedaKazunori Tomono
Author information
JOURNAL OPEN ACCESS Advance online publication

Article ID: 8774-16

Details
Abstract

Ceftriaxone is a widely used third-generation cephalosporin showing advantageous pharmacokinetic properties and a broad antimicrobial spectrum. We herein report a case of ceftriaxone-induced neurotoxicity in a 56-year-old man on hemodialysis. Seven days after initiating high-dose ceftriaxone, the patient developed impaired consciousness along with facial myoclonus and sporadic phonation. The symptoms clearly disappeared shortly after withdrawal of the drug. Ceftriaxone is considered a safe antibiotic for patients with renal insufficiency, since it is excreted via both haptic and renal pathways. Physicians should note that antibiotic-associated encephalopathy may develop in patients administered ceftriaxone, especially in those complicated with renal dysfunction.

Content from these authors
© 2017 by The Japanese Society of Internal Medicine
feedback
Top