Isolated Pancreatic Myeloid Sarcoma Associated with t(8;21)/RUNX1-RUNX1T1 Rearrangement

Kenji Tokunaga; Ayako Yamamura; Shikiko Ueno; Yoshitaka Kikukawa; Shunichiro Yamaguchi; Michihiro Hidaka; Naofumi Matsuno; Tatsuya Kawaguchi; Masao Matsuoka; Yutaka Okuno

doi:10.2169/internalmedicine.8912-17

This article has now been updated. Please use the final version.

Isolated Pancreatic Myeloid Sarcoma Associated with t(8;21)/RUNX1-RUNX1T1 Rearrangement

Kenji Tokunaga, Ayako Yamamura, Shikiko Ueno, Yoshitaka Kikukawa, Shunichiro Yamaguchi, Michihiro Hidaka, Naofumi Matsuno, Tatsuya Kawaguchi, Masao Matsuoka, Yutaka Okuno

Author information

Kenji Tokunaga
Department of Hematology, Rheumatology, and Infectious Diseases, Faculty of Life Sciences, Kumamoto University, Japan
Ayako Yamamura
Department of Hematology, Rheumatology, and Infectious Diseases, Faculty of Life Sciences, Kumamoto University, Japan
Shikiko Ueno
Department of Hematology, Rheumatology, and Infectious Diseases, Faculty of Life Sciences, Kumamoto University, Japan
Yoshitaka Kikukawa
Department of Hematology, Rheumatology, and Infectious Diseases, Faculty of Life Sciences, Kumamoto University, Japan
Shunichiro Yamaguchi
Department of Hematology, National Hospital Organization Kumamoto Medical Center, National Hospital Organization Kumamoto Medical Center, Japan
Michihiro Hidaka
Department of Hematology, National Hospital Organization Kumamoto Medical Center, National Hospital Organization Kumamoto Medical Center, Japan
Naofumi Matsuno
Department of Hematology, Rheumatology, and Infectious Diseases, Faculty of Life Sciences, Kumamoto University, Japan
Tatsuya Kawaguchi
Department of Hematology, Rheumatology, and Infectious Diseases, Faculty of Life Sciences, Kumamoto University, Japan
Masao Matsuoka
Department of Hematology, Rheumatology, and Infectious Diseases, Faculty of Life Sciences, Kumamoto University, Japan
Yutaka Okuno
Department of Hematology, Rheumatology, and Infectious Diseases, Faculty of Life Sciences, Kumamoto University, Japan

Keywords: isolated myeloid sarcoma, t(8;21), pancreas

JOURNAL OPEN ACCESS Advance online publication

Article ID: 8912-17

DOI https://doi.org/10.2169/internalmedicine.8912-17

The final version of this article is now available: Vol. 57 (2018), No. 4 pp. 563-568

Details

Abstract

No valid treatment for isolated myeloid sarcoma (IMS) has yet been established, and no thorough genetic examinations have been performed because of its low incidence and unique manner of development. We herein report a 34-year-old man with pancreatic IMS with t(8;21)/RUNX1-RUNX1T1 rearrangement. He was treated with high-dose cytarabine followed by allogeneic hematopoietic stem cell transplantation (allo-HSCT). This is the first report of pancreatic IMS with t(8;21). Positron emission tomography/computed tomography and genetic study are useful for the diagnosis, and allo-HSCT achieved complete remission in this patient.

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