Reversible Hyperkalemia Induced by Flufenamic Acid in Asymptomatic Hyporeninemic Patient

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Reversible hyperkalemia induced by flufenamic acid in an asymptomatic hyporenemic patient with IgA nephropathy is reported. Flufenamic acid, 600 mgdaily, was given for four months to a 64-yearold womanwith biopsy proven IgA-nephropathy. This produced hyperkalemia, hypertension and congestive heart failure with slowly progressive renal impairment. Weconclude that a further suppression of the renin angiotensin system causing selective hypoaldosteronism together with the nephrotoxic effects of this drug mayhave been responsible for hyperkalemia in this patient.