Four Cases with Intrafamilial Clustering of Hepatitis C Virus Infection

Michiko TAKAHASHI; Gotaro YAMADA; Toshihiko DOI; Hisashi ENDO; Hiroshi NISHIMOTO; Kouichi TAKAGUCHI; Kazuhiro MATSUEDA; Shigeatsu FUJIKI; Motowo MIZUNO; Shingo KINOYAMA; Takao TSUJI

doi:10.2169/internalmedicine.31.224

Michiko TAKAHASHI, Gotaro YAMADA, Toshihiko DOI, Hisashi ENDO, Hiroshi NISHIMOTO, Kouichi TAKAGUCHI, Kazuhiro MATSUEDA, Shigeatsu FUJIKI, Motowo MIZUNO, Shingo KINOYAMA, Takao TSUJI

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Keywords: household contact, epidemiology, antibody to HCV

JOURNAL FREE ACCESS

1992 Volume 31 Issue 2 Pages 224-226

DOI https://doi.org/10.2169/internalmedicine.31.224

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Abstract

Four hepatitis C patients with intrafamilial clustering of hepatitis C virus (HCV) infection are reported. Antibodies to C100-3 antigen, capsid protein of HCV and GOR epitope were tested to detect histories of HCV infection. Transmission of HCV from mother to children, from father to children, and from wife to husband was implicated. Of all family members studied, three were positive for all antibodies, one for only antibody to capsid protein, two for antibodies to capsid protein and GOR epitope but negative for antibody to C100-3 antigen and onevice versa.
(Internal Medicine 31 : 224-226, 1992)

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