Four Cases with Intrafamilial Clustering of Hepatitis C Virus Infection

Michiko TAKAHASHI; Gotaro YAMADA; Toshihiko DOI; Hisashi ENDO; Hiroshi NISHIMOTO; Kouichi TAKAGUCHI; Kazuhiro MATSUEDA; Shigeatsu FUJIKI; Motowo MIZUNO; Shingo KINOYAMA; Takao TSUJI

doi:10.2169/internalmedicine.31.224

Michiko TAKAHASHI, Gotaro YAMADA, Toshihiko DOI, Hisashi ENDO, Hiroshi NISHIMOTO, Kouichi TAKAGUCHI, Kazuhiro MATSUEDA, Shigeatsu FUJIKI, Motowo MIZUNO, Shingo KINOYAMA, Takao TSUJI

Author information

Michiko TAKAHASHI
The First Department of Internal Medicine, Okayama University Medical School
Gotaro YAMADA
The First Department of Internal Medicine, Okayama University Medical School
Toshihiko DOI
The First Department of Internal Medicine, Okayama University Medical School
Hisashi ENDO
The First Department of Internal Medicine, Okayama University Medical School
Hiroshi NISHIMOTO
The First Department of Internal Medicine, Okayama University Medical School
Kouichi TAKAGUCHI
The First Department of Internal Medicine, Okayama University Medical School
Kazuhiro MATSUEDA
The First Department of Internal Medicine, Okayama University Medical School
Shigeatsu FUJIKI
The First Department of Internal Medicine, Okayama University Medical School
Motowo MIZUNO
The First Department of Internal Medicine, Okayama University Medical School
Shingo KINOYAMA
The First Department of Internal Medicine, Okayama University Medical School
Takao TSUJI
The First Department of Internal Medicine, Okayama University Medical School

Keywords: household contact, epidemiology, antibody to HCV

JOURNAL FREE ACCESS

1992 Volume 31 Issue 2 Pages 224-226

DOI https://doi.org/10.2169/internalmedicine.31.224

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Abstract

Four hepatitis C patients with intrafamilial clustering of hepatitis C virus (HCV) infection are reported. Antibodies to C100-3 antigen, capsid protein of HCV and GOR epitope were tested to detect histories of HCV infection. Transmission of HCV from mother to children, from father to children, and from wife to husband was implicated. Of all family members studied, three were positive for all antibodies, one for only antibody to capsid protein, two for antibodies to capsid protein and GOR epitope but negative for antibody to C100-3 antigen and onevice versa.
(Internal Medicine 31 : 224-226, 1992)

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