Ovarian and Hepatic Metastases of Gastric Carcinoma Associated with High Serum Levels of Human Chorionic Gonadotropin (hCG), Alpha-Fetoprotein (AFP), and Carcinoembryonic Antigen (CEA) : A Case Report

Masataka SANO; Yukio INAMOTO; NAGAMINE NAGAMINE; Haruo YAMADA; Masao OGIWARA; Shoichi SEKINO; Yoshiaki HIRAMA; Masahiro AOKI; Hiroshi HANO; Tadakazu SHIMODA; Muneo KAWAMURA

doi:10.2169/internalmedicine.31.260

Masataka SANO, Yukio INAMOTO, NAGAMINE NAGAMINE, Haruo YAMADA, Masao OGIWARA, Shoichi SEKINO, Yoshiaki HIRAMA, Masahiro AOKI, Hiroshi HANO, Tadakazu SHIMODA, Muneo KAWAMURA

Author information

Masataka SANO
Departments of Internal Medicine, Fuji Central Hospital
Yukio INAMOTO
Departments of Internal Medicine, Fuji Central Hospital
NAGAMINE NAGAMINE
Departments of Internal Medicine, Fuji Central Hospital
Haruo YAMADA
Departments of Internal Medicine, Fuji Central Hospital
Masao OGIWARA
Departments of Internal Medicine, Fuji Central Hospital
Shoichi SEKINO
Departments of Obstetrics and Gynecology, Fuji Central Hospital
Yoshiaki HIRAMA
Departments of Obstetrics and Gynecology, Fuji Central Hospital
Masahiro AOKI
Departments of Obstetrics and Gynecology, Fuji Central Hospital
Hiroshi HANO
Departments of Pathology, Fuji Central Hospital
Tadakazu SHIMODA
Department of Pathology, The Jikei University School of Medicine
Muneo KAWAMURA
Kawamura Hospital

Keywords: immunohistochemical study, tumor marker

JOURNAL FREE ACCESS

1992 Volume 31 Issue 2 Pages 260-264

DOI https://doi.org/10.2169/internalmedicine.31.260

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Abstract

A 45-year-old woman who underwent gastrectomy for gastric carcinoma which had metastasized to the liver and ovaries, showed high serum levels of hCG, AFP and CEA. To locate the source, an immunohistochemical technique was utilized. HCG-producing cells were detected in poorly differentiated adenocarcinoma of a primary tumor and an ovarian metastatic site, and AFP-producing cells in poorly differentiated adenocarcinoma forming a medullarypattern of primary site and metastatic foci. CEA-producing cells were found diffused in primary tumor and metastatic foci. From the viewpoint of oncodevelopmental gene expression (Cancer Res 36 : 3423, 1976), it is interesting that the serum levels of these three tumor markers (hCG, AFP, CEA) were elevated simultaneously.
(Internal Medicine 31 : 260-264, 1992)

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