Hemoglobin Andrew-Minneapolis (β144 (HCl) Lysine→Asparagine) in a Japanese Family

Abstract

Hemoglobin Andrew-Minneapolis, an abnormal hemoglobin with an asparagine residue substituted for a lysine at position 144 of the β-globulin chains, was identified in three members of two generations in a Japanese family. The carriers of hemoglobin Andrew-Minneapolis showed false high levels of hemoglobin A₁c, as measured by the standard cation exchange high performance liquid chromatography, and a moderate tendency for erythrocytosis. This family is the first report of this abnormal hemogloblin in Japan.
(Internal Medicine 31 : 659-661, 1992)