Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Evaluation of Antibody against AR142, a Synthetic Peptide Derived from the Core Sequence of Hepatitis C Virus, in the Diagnosis of Non-A, Non-B Chronic Liver Disease
Lina DUHiroyuki SHIMOMURAHiroshi NAKAGAWAToshimi HASUIHideyuki TSUJIMasaki WATOJunichi KONDOMinoru UKIDAGotaro YAMADATakao TSUJI
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1993 Volume 32 Issue 11 Pages 843-848

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Abstract

We evaluated serum anti-hepatitis C virus (HCV) using a synthetic peptide (AR142) which includes an epitope in the core region of HCV. The incidence of anti-AR142 in 98 patients with type non-A, non-B chronic liver diseases (NANB-CLD)was 89.8%, while all the 28 patients with nontype C chronic liver diseases were negative for anti-AR142. Among 98 NANB-CLD patients, 74 were positive for both anti-AR142 and anti-C100-3, 23 showed discordant results, and one was positive for neither. Eighty-one NANB-CLD patients underwent reverse transcription-polymerase chain reaction assay to detect viremia and 76 (93.8%) had a detectable level of HCV-RNA. Titers of anti-AR142 were not different among groups of different disease activities, genotypes of HCV, nor amount of serum HCV-RNA. These observations suggest that anti-AR142 could be a useful marker for chronic HCV infection.
(Internal Medicine 32: 843-848, 1993)

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