Exacerbation of Ulcerative Colitis during Alpha-Interferon Therapy for Chronic Hepatitis C

Akira MITORO; Masahide YOSHIKAWA; Kouji YAMAMOTO; Mayumi MIMURA; Yoshitsugu YOSHIKAWA; Akira SHIROI; Tadao MOCHI; Takemi SAKAMOTO; Junichi YAMAO; Eiryou KIKUCHI; Hiroshi FUKUI; Tadasu TSUJII

doi:10.2169/internalmedicine.32.327

Akira MITORO, Masahide YOSHIKAWA, Kouji YAMAMOTO, Mayumi MIMURA, Yoshitsugu YOSHIKAWA, Akira SHIROI, Tadao MOCHI, Takemi SAKAMOTO, Junichi YAMAO, Eiryou KIKUCHI, Hiroshi FUKUI, Tadasu TSUJII

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Keywords: sulfasalazine, autoimmune disorders

JOURNAL FREE ACCESS

1993 Volume 32 Issue 4 Pages 327-331

DOI https://doi.org/10.2169/internalmedicine.32.327

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Abstract

We report a 34-year-old man with chronic hepatitis C who showed exacerbation of ulcerative colitis during alpha-interferon (IFNα) therapy. Discontinuance of the IFNα therapy improved his symptoms, suggesting that IFNα administration might worsen ulcerative colitis. The administration of sulfasalazine allowed the patient to receive IFNα again without flare-up of ulcerative colitis. This case suggests the possible efficacy of sulfasalazine therapy in patients with ulcerative colitis complicated by some other diseases requiring IFNα administration.
(Internal Medicine 32: 327-331, 1993)

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