Immune Complex Type Crescentic Glomerulonephritis Accompanied with Perinuclear Anti-Neutrophil Cytoplasmic Antibodies

Atsushi Komatsuda; Tadashi Yasuda; Hideki Wakui; Hirokazu Imai; Akira B Miura; Masafumi Sakuyama; Takashi Fukuda; Yasushi Nakamoto

doi:10.2169/internalmedicine.32.387

Atsushi Komatsuda, Tadashi Yasuda, Hideki Wakui, Hirokazu Imai, Akira B Miura, Masafumi Sakuyama, Takashi Fukuda, Yasushi Nakamoto

Author information

Atsushi Komatsuda
the Third Department of Internal Medicine, Akita University School of Medicine
Tadashi Yasuda
the Third Department of Internal Medicine, Akita University School of Medicine
Hideki Wakui
the Third Department of Internal Medicine, Akita University School of Medicine
Hirokazu Imai
the Third Department of Internal Medicine, Akita University School of Medicine
Akira B Miura
the Third Department of Internal Medicine, Akita University School of Medicine
Masafumi Sakuyama
the Department of Internal Medicine and Urology, Akita Rohsai Hospital
Takashi Fukuda
the Department of Internal Medicine and Urology, Akita Rohsai Hospital
Yasushi Nakamoto
the Department of Internal Medicine, Mitaka Kitaguchi Hospital

Keywords: ANCA-associated renal diseases

JOURNAL FREE ACCESS

1993 Volume 32 Issue 5 Pages 387-390

DOI https://doi.org/10.2169/internalmedicine.32.387

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Abstract

A 70-year-old male developed rapidly progressive glomerulonephritis syndrome with serum perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCA). A renal biopsy showed diffuse crescentic glomerulonephritis. Immunofluorescence microscopy revealed 2+ granular staining of IgG over the mesangial area and along glomerular capillary walls. Electron microscopy showed scattered deposits in the paramesangial area. These morphologic findings were consistent with those of immune complex type crescentic glomerulonephritis (IC-CGN). Serum C3, C4, and CH50 were within normal limits, and circulating immunecomplexes were not detected by Clq-binding assay, but both P-ANCA and anti-myeloperoxidase antibodies were positive. A possible relation of P-ANCA to IC-CGN is discussed.
(Internal Medicine 32: 387-390, 1993)

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