Familial Primary Hyperparathyroidism Complicated with Wilms' Tumor

Ayumu KAKINUMA; Isao MORIMOTO; Yoichiro NAKANO; Ryouji FUJIMOTO; Osamu ISHIDA; Yosuke OKADA; Nobuo INOKUCHI; Takashi FUJIHIRA; Sumiya ETO

doi:10.2169/internalmedicine.33.123

Ayumu KAKINUMA, Isao MORIMOTO, Yoichiro NAKANO, Ryouji FUJIMOTO, Osamu ISHIDA, Yosuke OKADA, Nobuo INOKUCHI, Takashi FUJIHIRA, Sumiya ETO

Author information

Keywords: multiple endocrine neoplasia, MEN, parathyroid cancer, cementifying jaw fibroma, parathyroid hormone

JOURNAL FREE ACCESS

1994 Volume 33 Issue 2 Pages 123-126

DOI https://doi.org/10.2169/internalmedicine.33.123

Details

Abstract

We describe a familial occurrence of primary hyperparathyroidism. The proband is a 60-yearold woman who had a parathyroid adenoma. Her older sister had a parathyroid adenoma with cementifying jaw fibroma and her younger sister died of parathyroid adenocarcinoma with pulmonary metastasis at the age of 38. We have not yet obtained evidence for other endocrine disorders suggesting multiple endocrine neoplasia (MEN) in this pedigree. The proband is complicated with Wilms' tumor. It is now widely accepted that respective predisposed genes of MEN type 1 and Wilms' tumor, and PTH gene are located on chromosome 11. The manifestation observed in this case may be related to mutational abnormalities on chromosome 11.
(Internal Medicine 33:123-126, 1994)

Corresponding author

Register with J-STAGE for free!