Autopsy Findings of Addison's Disease Caused by Systemic Cytomegalovirus Infection in a Patient with Acquired Immunodeficiency Syndrome

Akiko TAKASAWA; Isao MORIMOTO; Atsushi WAKE; Joji HARATAKE; Koichi FUJII; Yohsuke OKADA; Susumu ODA; Hiroshi HASHIMOTO; Sumiya ETO

doi:10.2169/internalmedicine.34.533

Akiko TAKASAWA, Isao MORIMOTO, Atsushi WAKE, Joji HARATAKE, Koichi FUJII, Yohsuke OKADA, Susumu ODA, Hiroshi HASHIMOTO, Sumiya ETO

Author information

Akiko TAKASAWA
the First Department of Internal Medicine, University of Occupational and Environmental Health
Isao MORIMOTO
the First Department of Internal Medicine, University of Occupational and Environmental Health
Atsushi WAKE
the First Department of Internal Medicine, University of Occupational and Environmental Health
Joji HARATAKE
the Department of Pathology and Oncology, University of Occupational and Environmental Health
Koichi FUJII
the First Department of Internal Medicine, University of Occupational and Environmental Health
Yohsuke OKADA
the First Department of Internal Medicine, University of Occupational and Environmental Health
Susumu ODA
the First Department of Internal Medicine, University of Occupational and Environmental Health
Hiroshi HASHIMOTO
the Department of Pathology and Oncology, University of Occupational and Environmental Health
Sumiya ETO
the First Department of Internal Medicine, University of Occupational and Environmental Health

Keywords: CMV adrenalitis, ganciclovir

JOURNAL FREE ACCESS

1995 Volume 34 Issue 6 Pages 533-536

DOI https://doi.org/10.2169/internalmedicine.34.533

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Abstract

We previously reported a case of Addison's disease associated with acquired immunodeficiency syndrome (AIDS) (Endocr J, 41: 13, 1994). A 46-year-old man with hemophilia B and AIDS was diagnosed as Addison's disease. The positive cytomegalovirus (CMV) antigen in urine suggested that CMV adrenalitis may have caused the adrenal insufficiency. Despite treatment with ganciclovir, the patient died one year later. Autopsy findings revealed that the typical inclusions of CMV were seen in the lung, adrenal glands (both cortex and medulla) and small intestine. Here, we describe the subsequent clinical course and postmortem findings of this case.
(Internal Medicine 34: 533-536, 1995)

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