Acute Myelomonocytic Leukemia in a Patient with Multiple Myeloma: Evidence for Different Clonal Origin

Kazunori NAKASE; Kota TSUJI; Masaki HASEGAWA; Yoshinori SUZUKI; Shigehisa TAMAKI; Motoaki TANIGAWA; Takeshi IKEDA; Eiki MIYANISHI

doi:10.2169/internalmedicine.34.546

Kazunori NAKASE, Kota TSUJI, Masaki HASEGAWA, Yoshinori SUZUKI, Shigehisa TAMAKI, Motoaki TANIGAWA, Takeshi IKEDA, Eiki MIYANISHI

Author information

Keywords: therapy-related leukemia, monosomy 7

JOURNAL FREE ACCESS

1995 Volume 34 Issue 6 Pages 546-549

DOI https://doi.org/10.2169/internalmedicine.34.546

Details

Abstract

A case of 77-year-old female with multiple myeloma (IgG-k) developed acute myelomonocytic leukemia (AMMoL) following a myelodysplastic stage after chemotherapy with melphalan-cyclophosphamide combinations for 6 years. The leukemic blast cells expressed both myeloid antigens (CDllb, CD13, CD14, CD15, CD33 and CD34) and T/B lymphoid antigens (CD2, CD4, CD22 and PCA1). Cytogenetic analysis revealed a chromosome deletion -7. Analysis of immunoglobulin genes showed the heavy chain genes in germ line configuration. These findings indicate that the AMMoL was a therapy-related stem cell leukemia and was a clonal origin genetically different from multiple myeloma irrespective of plasma cell phenotype.
(Internal Medicine 34: 546-549, 1995)

Corresponding author

Register with J-STAGE for free!